Evidence map›Paper›PMID 41233688›Full record

ArticleIntensive care medicine experimental2025

Reversible impairment of non-invasively assessed mitochondrial oxygen metabolism in the long-term course of patients with sepsis: a prospective monocentric cohort study.

Anne Standke, Charles Neu, Philipp Baumbach, Alina K Plooij, Kornel Skitek, Juliane Götze, Sina M Coldewey

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03620409 (Identification of Cardiovascular and Molecular Prognostic Factors for the Mid- and Long-term Outcome of Sepsis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03620409 completednot on this map

Identification of Cardiovascular and Molecular Prognostic Factors for the Mid- and Long-term Outcome of Sepsis

TypeobservationalSponsorJena University HospitalRan2018 to 2022Enrolled308ConditionsSepsis, Septic Cardiomyopathy, Cardiomyopathies
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anne StandkeDepartment of Anaesthesiology and Intensive Care Medicine, Septomics Research Centre, Translational Septomics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.ORCID http://orcid.org/0009-0004-3002-2240
Charles NeuDepartment of Anaesthesiology and Intensive Care Medicine, Septomics Research Centre, Translational Septomics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.ORCID http://orcid.org/0000-0002-5738-6720
Philipp BaumbachDepartment of Anaesthesiology and Intensive Care Medicine, Septomics Research Centre, Translational Septomics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.ORCID http://orcid.org/0000-0002-7815-6924
Alina K PlooijDepartment of Anaesthesiology and Intensive Care Medicine, Septomics Research Centre, Translational Septomics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.ORCID http://orcid.org/0009-0005-7620-3538
Kornel SkitekDepartment of Anaesthesiology and Intensive Care Medicine, Septomics Research Centre, Translational Septomics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.ORCID http://orcid.org/0009-0002-7637-1265
Juliane GötzeDepartment of Anaesthesiology and Intensive Care Medicine, Septomics Research Centre, Translational Septomics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.ORCID http://orcid.org/0009-0007-9584-7958
Sina M ColdeweyDepartment of Anaesthesiology and Intensive Care Medicine, Septomics Research Centre, Translational Septomics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. sina.coldewey@uzh.ch.ORCID http://orcid.org/0000-0002-7130-0006

Funding

Bundesministerium für Bildung und Forschung 03COV07Bundesministerium für Bildung und Forschung 03Z22JN12
6 · The paper itself

Abstract

backgroundSepsis is characterized by organ dysfunction due to infection, with increasing evidence of mitochondrial dysfunction assessed preclinically and invasively. Protoporphyrin IX-triplet state lifetime technique (PpIX-TSLT) permits non-invasive determination of cellular oxygen metabolism and may provide deeper pathophysiological insights.

methodsThis analysis is part of a prospective monocentric cohort study. ICU patients with sepsis and septic shock and healthy controls were enrolled between May 2018 and June 2022. Mitochondrial oxygen tension (mitoPO

resultsIn the acute phase, mitochondrial oxygen tension (mitoPO

conclusionsOur results suggest that cellular oxygen metabolism in sepsis is characterized by a reversible restriction of oxygen tension without an impairment of mitochondrial oxygen consumption. Additionally, oxygen delivery is dependent on disease severity. These findings should be re-validated in a larger cohort.

trial registrationNCT03620409 (Ethics vote: 5276-09/17; German Register of Clinical Studies: DRKS00013347), Principal investigator: Sina M. Coldewey, Date of Registration: 11-30-2017 NCT03620409.

Indexed as

Cellular oxygen metabolism monitorMitochondrial oxygen consumptionMitochondrial oxygen deliveryMitochondrial oxygen tensionProtoporphyrin IX-triplet state lifetime technique (PpIX-TSLT)

Identifiers

PMID41233688
PMCPMC12615860

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.