Evidence map›Paper›PMID 41233631›Full record

ArticleClinical rheumatology2026

Cost optimizing tocilizumab therapy in stable rheumatoid arthritis: a dose de-escalation nomogram to prevent overuse and unnecessary costs.

Kaja van Soest, Sofia Ramiro, Mirian J F Starmans-Kool, Nieko C Punt, Robert B M Landewé, Niels W Boone

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kaja van SoestZuyderland MC, Clinical Pharmacy, Pharmacology and Toxicology, Heerlen, Netherlands. k.van.soest@hotmail.com.ORCID http://orcid.org/0009-0005-8131-796X
Sofia RamiroZuyderland MC, Rheumatology, Heerlen, Netherlands.ORCID http://orcid.org/0000-0002-8899-9087
Mirian J F Starmans-KoolZuyderland MC, Rheumatology, Heerlen, Netherlands.
Nieko C PuntMedimatics, Maastricht, Netherlands.ORCID http://orcid.org/0000-0002-7655-6094
Robert B M LandewéZuyderland MC, Rheumatology, Heerlen, Netherlands.ORCID http://orcid.org/0000-0002-0577-6620
Niels W BooneZuyderland MC, Clinical Pharmacy, Pharmacology and Toxicology, Heerlen, Netherlands.ORCID http://orcid.org/0000-0002-4236-2726

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe conventional 8 mg/kg tocilizumab (TCZ) dose regimen for rheumatoid arthritis (RA) yields higher serum trough concentrations (TCZ

methodsThis prospective cohort study examined RA patients with stable disease activity undergoing intravenous TCZ treatment. A population PK model was constructed utilizing literature PK-data, TCZ

resultsIn 39 patients treated according to the registered dose-scheme, the baseline mean TCZ

conclusionsTCZ

Indexed as

Antibodies, Monoclonal, HumanizedAntirheumatic AgentsArthritis, RheumatoidNomogramsAdultAgedDose-Response Relationship, DrugFemaleHumansMaleMiddle AgedProspective StudiesAntibodies, Monoclonal, HumanizedAntirheumatic AgentstocilizumabPharmacokineticsRheumatoid ArthritisTherapeutic drug monitoringTocilizumab

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.