Evidence map›Paper›PMID 41233623›Full record

ArticleHuman cell2025

Interaction between gastric cancer organoids and peritoneal mesothelial cells suppresses the growth of gastric cancer organoids and induces drug resistance.

Hiroyuki Uematsu, Shota Shimizu, Kunishige Onuma, Roberto Coppo, Yumi Sato, Tomoyuki Matsunaga, Yoshiyuki Fujiwara, Masahiro Inoue

Abstract read
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In one paragraph

Article in Human cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hiroyuki UematsuDepartment of Clinical Bio-Resource Research and Development, Graduate School of Medicine, Kyoto University, Med-Pharm Collaboration Building 503, 46-29, Shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Shota ShimizuDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.
Kunishige OnumaDepartment of Clinical Bio-Resource Research and Development, Graduate School of Medicine, Kyoto University, Med-Pharm Collaboration Building 503, 46-29, Shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Roberto CoppoDepartment of Clinical Bio-Resource Research and Development, Graduate School of Medicine, Kyoto University, Med-Pharm Collaboration Building 503, 46-29, Shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Yumi SatoDepartment of Basic Pathology, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan.
Tomoyuki MatsunagaDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.
Yoshiyuki FujiwaraDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.
Masahiro InoueDepartment of Clinical Bio-Resource Research and Development, Graduate School of Medicine, Kyoto University, Med-Pharm Collaboration Building 503, 46-29, Shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan. masa_inoue@kuhp.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0001-7315-026X

Funding

Japan Society for the Promotion of Science 22K08893
6 · The paper itself

Abstract

The prognosis of gastric cancer with peritoneal dissemination is poor because of its resistance to chemotherapy. To investigate the mechanism of drug resistance in peritoneal metastasis, cancer organoids were established from the ascites of a patient with peritoneal metastases of gastric cancer. The histological characteristics of the tumors were preserved in the organoids. A co-culture system was established by overlaying human-derived mesothelial cells on gastric cancer organoids embedded in type IA collagen, mimicking peritoneal dissemination foci. When co-cultured with mesothelial cells, the proliferation of ascites-derived gastric cancer organoids and other primary gastric cancer organoids was suppressed. Soluble factors derived from mesothelial cells were involved in suppressing cell proliferation. Organoids in co-culture showed reduced sensitivity to paclitaxel. This co-culture model may provide a useful platform for studying drug resistance mechanisms in the microenvironment of gastric cancer peritoneal metastases.

Indexed as

Drug Resistance, NeoplasmOrganoidsPeritoneal NeoplasmsPeritoneumStomach NeoplasmsAscitesCell ProliferationCoculture TechniquesEpitheliumHumansPaclitaxelTumor MicroenvironmentPaclitaxelCo-cultureGastric cancerMesothelial cellOrganoidPeritoneal dissemination

Identifiers

PMID41233623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.