ArticleJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2025
Bridge to heart transplantation with nearly 800-day intracorporeal biventricular assistance in a pediatric patient with Danon disease: a case report.
Article in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Danon disease is a rare inherited disorder, and its prognosis is significantly impacted by cardiac complications. Because of the severe shortage of donors, a ventricular assist device (VAD) is necessary as a bridge to heart transplantation. However, reports on VAD implantation for cardiomyopathy in Danon disease patients are limited. Herein, we report a successful pediatric case with nearly 800-day of biventricular assistance as a bridge to heart transplantation. A 12-year-old girl with severe heart failure due to hypertrophic cardiomyopathy associated with Danon disease underwent left implantation of a Heartware VAD (Heartware Inc., Miami Lakes, FL, USA). Owing to severe right ventricular failure, she was unable to be weaned off the cardiopulmonary bypass, and a right VAD implantation was undertaken using a Gyro pump (Kyosera, Kyoto, Japan). However, the right ventricular function did not recover postoperatively, and she subsequently underwent right implantation of a Heartware VAD on postoperative day 34. Despite several VAD-related complications, including aortic and pulmonary valve insufficiency and a driveline infection requiring hospitalization, the patient was able to attend junior high school during the waiting period for a heart transplantation. After a total waiting period of 882 days, including 791 days of biventricular Heartware VAD assistance, the patient underwent a heart transplantation.
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