ArticleCommunications medicine2025
Investigation of the sero-epidemiology of vaccine preventable diseases and common viral infections in French populations.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- A multiplex serological assay for quantification of arbovirus antibody kinetics and neutralizing antibodies.PLoS neglected tropical diseases · 2026Article
- Reconstruction of historical malaria transmission in Senegal using multiplex serocatalytic models.PLoS computational biology · 2026Article
- An integrative approach for studying immunological variation in an aging population - The Milieu Intérieur follow-up study.Nature communications · 2026Article
- Whose Line Is it Anyway? Defining Seropositivity Cutoffs for Infectious Disease Surveillance.The Journal of infectious diseases · 2026Article
- Investigating antibody cross-reactivity and transmission dynamics of alphaviruses and flaviviruses using a multiplex serological assay.Nature communications · 2026Article
- Impaired serum neutralization and death in Omicron-infected critically ill patients: insights from the French SEVARVIR prospective, multicenter cohort study.Intensive care medicine experimental · 2025Article
- A Multiplex Serological Assay for the Detection of Antibody Responses to Arboviruses.Journal of visualized experiments : JoVE · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundVaccine-preventable diseases and common viral infections pose substantial public health challenges worldwide. Applying multiplex serological assays to samples collected from cross-sectional studies allows assessment of population-level immunity to a broad range of pathogens.
methodsWe develop a high-throughput multiplex serological assay using bead-based Luminex technology to measure IgG antibody responses to a broad panel of pathogens. Vaccine preventable diseases include pertussis, diphtheria, tetanus, measles, mumps, and rubella. Common viral infections include adenovirus, cytomegalovirus, Epstein-Barr virus, chickenpox, respiratory syncytial virus, echovirus, Coxsackie B virus, rhinovirus, norovirus, rotavirus, influenza A, hepatitis A, hepatitis E, and the seasonal coronaviruses 229E, OC43, NL63, and HKU1. Measured antibody responses are analysed with statistical models to assess seroprevalence within the French population.
resultsThe analysis of 2132 serum samples from French children and adults reveals notable variation in seroprevalence among different age groups. Consistently high seroprevalence for endemic viruses is observed across all age groups, suggesting widespread exposure from a young age and continuous exposure throughout life. Similarly, mandatory vaccine seroprevalence remains consistently high, reflecting a strong vaccination coverage in France.
conclusionsThese findings highlight the potential of high-throughput multiplex serology assays for routine surveillance of common viral infections and assessment of vaccine coverage.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.