ArticleNature cardiovascular research2025
Gene therapy CM-YAP
Abstract read
In one paragraph
Article in Nature cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Alpha protein kinase 3 gene therapy restores heart function in mouse and human models of cardiomyopathy.Nature cardiovascular research · 2026Article
- NUAK1 Inhibition Alleviates Ischemia-Reperfusion Injury via SYNE1-YAP1.Circulation research · 2026Article
- Synthetic control of implanted engineered liver tissue growth.Science advances · 2026Article
- Mechanisms and Therapeutic Potential of Human Cardiomyocyte Proliferation.Journal of cardiovascular development and disease · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Fansen MengMcGill Gene Editing Lab, The Texas Heart Institute at Baylor College of Medicine, Houston, TX, USA.
Jeffrey D SteimleDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-1369-9661
Elizabeth StraightCardiomyocyte Renewal Laboratory, The Texas Heart Institute at Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0009-0008-2050-4042
Rich G LiMcGill Gene Editing Lab, The Texas Heart Institute at Baylor College of Medicine, Houston, TX, USA.
Yuka MorikawaCardiomyocyte Renewal Laboratory, The Texas Heart Institute at Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-4571-8409
Zohaib IqbalDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.
Bing XieDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.
Jun WangCardiomyocyte Renewal Laboratory, The Texas Heart Institute at Baylor College of Medicine, Houston, TX, USA.
Wyatt G PaltzerDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-9142-4217
Yi ZhaoMcGill Gene Editing Lab, The Texas Heart Institute at Baylor College of Medicine, Houston, TX, USA.
Chang-Ru TsaiDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.
Lin LiuMcGill Gene Editing Lab, The Texas Heart Institute at Baylor College of Medicine, Houston, TX, USA.
Maggie LimMcGill Gene Editing Lab, The Texas Heart Institute at Baylor College of Medicine, Houston, TX, USA.
Rita A SchackDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.
Daniel RamirezDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0009-0002-9582-3968
Katherine CarlsonMcGill Gene Editing Lab, The Texas Heart Institute at Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0009-0001-7066-7754
Vaibhav DeshmukhDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-0087-7545
Jason M KarchDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-3023-7469
Robia G PautlerDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.
Xiao LiMcGill Gene Editing Lab, The Texas Heart Institute at Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-8527-4438
James F MartinMcGill Gene Editing Lab, The Texas Heart Institute at Baylor College of Medicine, Houston, TX, USA. JFMartin@bcm.edu.ORCID http://orcid.org/0000-0002-7842-9857
Funding
Hippo and Wnt Signaling in Cardiac RegenerationR01HL127717 · NHLBI · TEXAS HEART INSTITUTE · PI MARTIN, JAMES F · 2016 to 2023
$4.4MGenetic dissection of Cardiac Conduction System homeostasis and RepairR01HL142704 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jun Wang · 2020 to 2026
$3.0MOptical elastography for assessment of myocardial regenerationR01HL130804 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LARIN, KIRILL V, MARTIN, JAMES F · 2016 to 2019
$2.9MHippo-YAP signaling in cardiac regenerative repairR01HL173242 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI James F Martin · 2025 to 2026
$1.4MSenescent Cell States in Single Ventricle Disease with Heart FailureR01HL177644 · NHLBI · TEXAS HEART INSTITUTE · PI James F Martin · 2025 to 2026
$1.3MTargeting Senescent Macrophages to Improve Heart Failure OutcomesR01HL179012 · NHLBI · TEXAS HEART INSTITUTE · PI LI, XIAO · 2025 to 2025
$1.3MLeft-right asymmetry and PITX2 in atrial fibrillationR00HL169742 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Jeffrey David Steimle · 2025 to 2026
$498kLeft-right asymmetry and PITX2 in atrial fibrillationK99HL169742 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI STEIMLE, JEFFREY DAVID · 2023 to 2024
$214kCOMPLEMENT IN THE CELLULAR MICROENVIRONMENT DURING CARDIAC RENEWALK99HL174827 · NHLBI · TEXAS HEART INSTITUTE · PI LI, RICH GANG · 2024 to 2025
$194kA Yap to Notch Transcriptional Activity Transition Governs Postnatal Cardiomyocyte MaturationF32HL182110 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Wyatt G Paltzer · 2025 to 2026
$152kAmerican Heart Association (American Heart Association, Inc.) 24CDA1274610American Heart Association (American Heart Association, Inc.) 903411American Heart Association (American Heart Association, Inc.) 903651American Heart Association-American Stroke Association 903411American Heart Association-American Stroke Association 903651NHLBI NIH HHS F32 HL182110NHLBI NIH HHS K99 HL169742NHLBI NIH HHS K99 HL174827NHLBI NIH HHS R00 HL169742NHLBI NIH HHS R01 HL127717NHLBI NIH HHS R01 HL130804NHLBI NIH HHS R01 HL142704NHLBI NIH HHS R01 HL173242NHLBI NIH HHS R01 HL177644NHLBI NIH HHS R01 HL179012U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL127717U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL130804U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL142704U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL173242U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL177644U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) K99HL174827
Abstract
Myocardial infarction (MI) affects millions of people worldwide, causing irreversible injury to the heart and impairing cardiac function
Indexed as
Adaptor Proteins, Signal TransducingCell Cycle ProteinsDependovirusGenetic TherapyMyocardial InfarctionMyocytes, CardiacAnimalsDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLVentricular Function, LeftYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsYap1 protein, mouseYAP-Signaling Proteins
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.