Evidence map›Paper›PMID 41233319›Full record

ArticleNature communications2025

Developmentally regulated genes drive phylogenomic splits in ovule evolution.

Veronica M Sondervan, Gil Eshel, Kranthi Varala, Samantha Frangos, Manpreet S Katari, Tim L Jeffers, Cecilia Zumajo-Cardona, Sebastiano Nigris, Lisa DeGironimo, Tynisha Smalls and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Veronica M SondervanDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0002-3927-8419
Gil EshelDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, NY, USA.
Kranthi VaralaDepartment of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN, USA.
Samantha FrangosDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, NY, USA.
Manpreet S KatariDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0002-3377-063X
Tim L JeffersDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, NY, USA.
Cecilia Zumajo-CardonaNew York Botanical Garden, Bronx, NY, USA.
Sebastiano NigrisDipartimento di Biologia, Università degli studi di Padova, Padova, Italy.
Lisa DeGironimoNew York Botanical Garden, Bronx, NY, USA.
Tynisha SmallsNew York Botanical Garden, Bronx, NY, USA.
W Richard McCombieCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Damon P LittleNew York Botanical Garden, Bronx, NY, USA. dlittle@nybg.org.ORCID http://orcid.org/0000-0001-9635-6164
Barbara AmbroseNew York Botanical Garden, Bronx, NY, USA. bambrose@nybg.org.ORCID http://orcid.org/0000-0002-9617-0148
Dennis Wm StevensonNew York Botanical Garden, Bronx, NY, USA. dws@nybg.org.ORCID http://orcid.org/0000-0002-2986-7076
Gloria M CoruzziDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, NY, USA. gloria.coruzzi@nyu.edu.ORCID http://orcid.org/0000-0003-2608-2166

Funding

The Quantitative Biological Systems Training (QBIST) ProgramT32GM132037 · NIGMS · NEW YORK UNIVERSITY · PI David Gresham, Christine Vogel · 2019 to 2026
$2.3M
EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 101007738National Science Foundation (NSF) NSF-PGRP:IOS-0922738National Science Foundation (NSF) NSF-PGRP:IOS-1758800NIGMS NIH HHS T32 GM132037
6 · The paper itself

Abstract

The evolution of seeds transformed life on earth and is responsible for our most important food crops. Gymnosperms, the oldest living seed plants, are an untapped genomic reservoir for genes involved in seed evolution. To tap this resource, we assemble deep transcriptomes of 14 gymnosperms, four angiosperms, and two ferns and identified 22,429 phylogenetically informative ortholog groups. We observe that genes differentially expressed in ovules or leaves provide the majority of phylogenomic support for the evolutionary splits between 1) seed and non-seed plants; 2) gymnosperms and angiosperms; and/or 3) within gymnosperms (conifers vs. "ancient" gymnosperms). Our gymnosperm data identifies unreported candidate ovule regulated genes in Arabidopsis. Moreover, prior knowledge from Arabidopsis helps uncover 4,076 candidate ovule genes that influence these evolutionary splits. We validate the expression of candidate ovule genes in gymnosperm-specific ovule structures. Our work provides a resource for seed gene discovery, conservation, and crop improvement.

Indexed as

Biological EvolutionCycadopsidaEvolution, MolecularGene Expression Regulation, DevelopmentalGene Expression Regulation, PlantOvulePhylogenyArabidopsisGene Expression ProfilingGenes, PlantMagnoliopsidaSeedsTranscriptome

Identifiers

PMID41233319
PMCPMC12615769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.