ArticleJournal of cardiac failure2025
Cardiac Dysfunction, Exercise Reserve, and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction With an Implanted Pacemaker.
Article in Journal of cardiac failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
backgroundPatients with heart failure with preserved ejection fraction (HFpEF) and a pacemaker have been shown to have an increased risk for adverse events and may respond differently to novel treatments such as atrial shunt devices. Whether there are pathophysiological differences in patients with HFpEF and a pacemaker is unknown. METHODS AND
resultsIndividuals with HFpEF with and without a pacemaker and noncardiac dyspnea underwent invasive hemodynamic exercise testing with simultaneous expired gas analysis for the evaluation of unexplained dyspnea. HFpEF with a pacemaker (HFpEF
conclusionsPrior pacemaker implantation in HFpEF is associated with more severe biventricular and biatrial dysfunction, impaired exercise capacity, and worse outcomes compared with those with no pacemaker. Further study is required to determine to what extent these differences are causally related to pacemakers or are confounding patient-specific differences associated with the need for pacemaker implantation.
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