ArticleSeminars in arthritis and rheumatism2025
Frailty carries an increased risk of death in rheumatoid arthritis.
Article in Seminars in arthritis and rheumatism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Frailty Predicts Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis.Arthritis care & research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
backgroundFrailty is prevalent among people with rheumatoid arthritis (RA) and is a risk factor for adverse outcomes, however the association between frailty and mortality in RA is not well understood.
methodsParticipants from the Veterans Association Rheumatoid Arthritis (VARA) Registry enrolled from 1/2003 to 12/2020 were included. Frailty was measured using the VA Frailty Index (VA-FI) which categorized participants as robust, pre-frail, mildly frail, and moderate/severely frail. Multivariable Cox proportional hazard modeling evaluated the relationship between baseline frailty and mortality, adjusted for demographics, disease activity, smoking, and disease treatments.
findings2792 Veterans were included with mean age of 64.3 years. 2457 (88 %) were male and 459 (17 %) were Black. Of these, 883 (32 %) were robust, 1112 (40 %) prefrail, 520 (19 %) mildly frail, and 277 (10 %) moderately to severely frail. In total, 1283 (46 %) of participants died during the 20 years of observation. The risk of mortality increased with increasing levels of frailty - prefrail aHR 1.46 [95 % CI 1.25 - 1.69], mild frailty aHR 1.97 [95 % CI 1.66 - 2.33], moderate/severe frailty aHR 2.93 [95 % CI 2.39 - 3.59]. The VA-FI frailty domains with the highest association with mortality were morbidities and functional impairments. INTERPRETATIONS: There is a stepwise increase in mortality risk and decrease in survival time, associated with higher degrees of frailty in RA. Morbidities and functional impairments are associated with the greatest risk increase of mortality. The VA-FI may serve as an important prognostic tool in the RA population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.