Evidence map›Paper›PMID 41232281›Full record

ArticleThe Science of the total environment2025

Associations between concurrent neonicotinoid, pyrethroid, and organophosphate insecticide metabolites and neurocognitive performance in Ecuadorian adolescents.

Jessica Yen, Kun Yang, Tuo Lin, Xin M Tu, Georgia Kayser, Rajendra P Parajuli, Ana Skomal, Sheila Gahagan, Jose Suarez-Torres, Suzi Hong and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Science of the total environment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jessica YenSchool of Medicine, University of California, San Diego (UCSD), La Jolla, California, CA, 92093, USA.
Kun YangHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA.
Tuo LinDepartment of Biostatistics, University of Florida, Division of Quantitative Sciences, University of Florida Health Cancer Center, Cancer Genetics Research Center, 2033 Mowry Road, Gainesville, FL, 32611, USA.
Xin M TuHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA.
Georgia KayserHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA.
Rajendra P ParajuliHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA.
Ana SkomalDepartment of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.
Sheila GahaganDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, 92093, USA.
Jose Suarez-TorresHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA; Fundación Cimas del Ecuador, Quito, Ecuador.
Suzi HongHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, 92093, USA.
Raeanne C MooreDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, 92093, USA.
Jose R Suarez-LopezHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, 92093, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92093, USA; Fundación Cimas del Ecuador, Quito, Ecuador. Electronic address: jrsuarez@health.ucsd.edu.

Funding

National Exposure Assessment Laboratory at EmoryU2CES026560 · NIEHS · EMORY UNIVERSITY · PI VOS, MIRIAM B. · 2015 to 2015
$8.3M
The ESPINA Study Follow-up Examination in 2016: Environmental Pollutants and Child/Adolescent DevelopmentR01ES025792 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Raeanne Cristine Moore, Jose Ricardo Suarez · 2016 to 2026
$5.6M
The ESPINA Study 19th Year Follow-Up: A Longitudinal Investigation of Pesticide Exposures in relation to Fertility and Hormonal HealthR01ES030378 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jose Ricardo Suarez · 2020 to 2026
$4.1M
Pesticide exposures, mental health and endocrine disruption among children growing up near pesticide spray sites.K01ES031697 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KAYSER, GEORGIA L. · 2020 to 2023
$594k
Pesticides and Mental Health among Adolescents in Ecuadorian Agricultural CommunitiesR21ES026084 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUAREZ, JOSE RICARDO · 2015 to 2016
$344k
NIEHS NIH HHS K01 ES031697NIEHS NIH HHS R01 ES025792NIEHS NIH HHS R01 ES030378NIEHS NIH HHS R21 ES026084NIEHS NIH HHS U2C ES026560NIOSH CDC HHS R36 OH009402
6 · The paper itself

Abstract

backgroundOrganophosphate and pyrethroid insecticides can affect children's neurodevelopment and increase inflammation. Limited evidence exists in adolescents, and whether inflammation mediates pesticide-neurobehavior associations. We tested whether concurrent urinary insecticide metabolites decrease neurocognitive performance among adolescents in Ecuadorian agricultural communities.

methodsWe analyzed 520 adolescents (12-17 years), measuring urinary insecticide metabolites and cognitive performance (NEPSY-II); associations were tested with generalized estimating equations, mediation via serum inflammatory biomarkers with structural equation modeling, and mixtures with Partial Least Squares regression.

resultsAmong organophosphates, para-nitrophenol (PNP) and 3,5,6-Trichloro-2-pyridinol (TCPy) were inversely associated with Social Perception (score difference per 50 % increase [beta coefficients (β)

conclusionsConcurrent organophosphate, pyrethroid, and mixtures of all metabolites assessed were associated with lower performance in 4 of 5 cognitive domains in adolescents. Pesticide reduction of people in agricultural settings should be prioritized.

Indexed as

CognitionEnvironmental ExposureEnvironmental PollutantsInsecticidesNeonicotinoidsOrganophosphatesPyrethrinsAdolescentChildEcuadorFemaleHumansMaleEnvironmental PollutantsInsecticidesNeonicotinoidsOrganophosphatesPyrethrinsAgricultureFloricultureInsecticidesLatin AmericaNeurocognitivePesticidesRural

Identifiers

PMID41232281
PMCPMC12834427

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.