Evidence map›Paper›PMID 41232031›Full record

ArticleACS nano2025

Single-Molecule and Super-Resolution Diffusion Quantification Unveils Reversible Enhancement of Lipid-Membrane Diffusivity by General Anesthetics.

Tyler Jepson, Hansen Jin, Chun Ying Wu, Wan Li, Ke Xu

Abstract read
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tyler JepsonDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0003-4701-4859
Hansen JinDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Chun Ying WuDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Wan LiDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0001-5751-3550
Ke XuDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-2788-194X

Funding

Intracellular transport and organelle biology at the nanoscale: A multidimensional super-resolution approachR35GM149349 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Ke Xu · 2023 to 2026
$1.8M
NIGMS NIH HHS R35 GM149349
6 · The paper itself

Abstract

The molecular mechanism of general anesthesia remains a mystery. While many small molecules, ranging from xenon to diethyl ether, act as general anesthetics, few similarities exist in their chemical structures or properties. Utilizing single-molecule displacement/diffusivity mapping (SM

Indexed as

Anesthetics, GeneralCell MembraneLipid BilayersSingle Molecule ImagingDiffusionHumansLiposomesMicroscopy, FluorescenceAnesthetics, GeneralLipid BilayersLiposomeschloride permeabilitygeneral anestheticslipid bilayer diffusionlipid bilayer orderlive-cell microscopysingle-molecule microscopysuper-resolution microscopy

Identifiers

PMID41232031
PMCPMC12659419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.