Evidence map›Paper›PMID 41231958›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Multiplexed and high-bandwidth DNA computing circuits with superresolution DNA origami displays.

Zhongchao Jin, Yuqing Tang, Sisi Jia, Zheze Dai, Zhikun Zhao, Jiang Li, Kai Xia, Jun Liu, Ke Ke, Hui Lv and 3 more

Abstract read
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In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

13 authors.

Zhongchao Jin *State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Yuqing Tang *State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Sisi JiaZhangjiang Laboratory, Shanghai 201210, China.
Zheze DaiState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Zhikun ZhaoState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0009-0004-8687-5613
Jiang LiInstitute of Materiobiology, College of Sciences, Shanghai University, Shanghai 200444, China.
Kai XiaJiaxing Key Laboratory of Biosemiconductors, Xiangfu Laboratory, Jiashan, Zhejiang 314102, China.
Jun LiuLenovo Research, Lenovo Group, Beijing 100094, China.
Ke KeLenovo Research, Lenovo Group, Beijing 100094, China.
Hui LvInstitute of Materiobiology, College of Sciences, Shanghai University, Shanghai 200444, China.
Qian LiState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Fei WangState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0003-3948-6899
Chunhai FanState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-7171-7338

Funding

K. C. Wong Education Foundation NAMOST | National Key Research and Development Program of China (NKPs) 2023YFA0915200National Natural Science Foundation of China T2188102 22322704 223B2404 U24A20497New Cornerstone Science Foundation NAShanghai Polit Program for Basic Research - Shanghai Jiao Tong University 21TQ1400222Xiangfu Lab Research Project XF012022E0100
6 · The paper itself

Abstract

DNA computing circuits leverage molecular interactions to construct a highly parallel and biologically compatible information processing paradigm. However, their development has been constrained by a critical gap between intrinsic computational parallelism and the limited readout bandwidth. Multibit outputs from complex circuits often require multiple separate tests, limiting the integration and debugging efficiency. Here, we overcome this bottleneck by decoupling computation from readout via a DNA origami display-based interface by integrating strand displacement and unstable binding reactions. We convert multibit molecular outputs from DNA circuits into spatially resolved geometric bits, enabling direct visualization via superresolution microscopy for high-throughput readout. We experimentally demonstrated the direct readout of an 8-bit decoder circuit and simultaneous display of 16 parallel-running logic gates. This high-bandwidth platform unlocks capabilities in circuit debugging and multiplexed execution, paving the way for large-scale DNA computing and high-throughput biosensing.

Indexed as

Computers, MolecularDNABiosensing TechniquesDNADNA computingDNA origamiDNA-PAINThigh-throughput readout

Identifiers

PMID41231958
PMCPMC12646223

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.