Evidence map›Paper›PMID 41231954›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Membrane-localized MET engages PVR to mediate extranuclear juvenile hormone signaling in

Wenhao Zhao, Katara Griffith, Jiangtao Liang, Maria Dorodnitsyna, Pengcheng Liu, Thomas R Saunders, Jinsong Zhu

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. MET goes to the membrane-A new place for the "old" juvenile hormone receptor.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Membrane-localized MET engages PVR to mediate extranuclear juvenile hormone signaling inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Wenhao ZhaoDepartment of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061.
Katara GriffithThe Interdisciplinary Ph.D. Program in Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061.
Jiangtao LiangDepartment of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061.ORCID 0000-0002-8468-7457
Maria DorodnitsynaDepartment of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061.ORCID 0009-0007-0626-3767
Pengcheng LiuDepartment of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061.
Thomas R SaundersDepartment of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061.
Jinsong ZhuDepartment of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061.ORCID 0000-0002-1587-753X

Funding

Molecular mechanism of juvenile hormone action in mosquito reproductionR01AI099250 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI JINSONG ZHU · 2012 to 2026
$3.3M
HHS | NIH (NIH) AI099250NIAID NIH HHS R01 AI099250USDA | National Institute of Food and Agriculture (NIFA) VA-160243
6 · The paper itself

Abstract

Although Methoprene-tolerant (MET) is well established as the intracellular receptor mediating the genomic actions of juvenile hormone (JH) in insects, the identity of the receptor responsible for initiating extranuclear JH responses has remained elusive. In the yellow fever mosquito

Indexed as

AedesInsect ProteinsJuvenile HormonesSignal TransductionAnimalsCell MembraneFat BodyFemalePhosphorylationInsect ProteinsJuvenile Hormonesinsectsjuvenile hormonereceptorreproductionsignal transduction

Identifiers

PMID41231954
PMCPMC12646218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.