Evidence map›Paper›PMID 41231953›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease.

Junwei Liu, Manuel Rogg, Katharina Moos, Shaya Sasanpour, Vera Strassl, Manaswita Jain, Sato Magassa, Björn Neubauer, Simone Braeg, Benedikt S Saller and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Junwei LiuRenal Department, Medical Center-University of Freiburg, Freiburg 79106, Germany.ORCID 0009-0008-3440-3453
Manuel RoggFaculty of Medicine, University of Freiburg, Freiburg 79085, Germany.ORCID 0000-0002-6658-9159
Katharina MoosFaculty of Medicine, University of Freiburg, Freiburg 79085, Germany.ORCID 0009-0007-9597-122X
Shaya SasanpourRenal Department, Medical Center-University of Freiburg, Freiburg 79106, Germany.
Vera StrasslRenal Department, Medical Center-University of Freiburg, Freiburg 79106, Germany.ORCID 0009-0000-2079-5726
Manaswita JainRenal Department, Medical Center-University of Freiburg, Freiburg 79106, Germany.
Sato MagassaRenal Department, Medical Center-University of Freiburg, Freiburg 79106, Germany.ORCID 0009-0004-8804-2965
Björn NeubauerRenal Department, Medical Center-University of Freiburg, Freiburg 79106, Germany.ORCID 0000-0002-2143-5316
Simone BraegRenal Department, Medical Center-University of Freiburg, Freiburg 79106, Germany.
Benedikt S SallerInstitute of Neuropathology, Medical Center-University of Freiburg, Freiburg 79106, Germany.
Lisa WeißerFaculty of Medicine, University of Freiburg, Freiburg 79085, Germany.
Frank BienaiméDepartment of Physiology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris 75015, France.
Oliver GorkaFaculty of Medicine, University of Freiburg, Freiburg 79085, Germany.ORCID 0000-0002-8245-3008
Melanie BoerriesFaculty of Medicine, University of Freiburg, Freiburg 79085, Germany.ORCID 0000-0002-3670-0602
Amandine ViauUniversité Paris Cité, Imagine Institute, Laboratory of Hereditary Kidney Diseases, INSERM UMR 1163, Paris 75015, France.ORCID 0000-0003-2890-7897
Olaf GrossFaculty of Medicine, University of Freiburg, Freiburg 79085, Germany.
Christoph SchellFaculty of Medicine, University of Freiburg, Freiburg 79085, Germany.
E Wolfgang KuehnRenal Department, Medical Center-University of Freiburg, Freiburg 79106, Germany.ORCID 0000-0002-7753-9616

Funding

Bundesministerium für Bildung und Forschung (BMBF) PM4Onco-FKZ 01ZZ2322ADeutsche Forschungsgemeinschaft (DFG) KU- 1504/8-1; KU- 1504/9-1; SFB 1453Deutsche Forschungsgemeinschaft (DFG) SFB 1160;SFB/TRR 167; SFB 1425; SFB 1479;GRK 2606; CIBSS - EXC-2189Deutsche Forschungsgemeinschaft (DFG) SFB1453; SCHE 2092/3-1; SCHE 2092/4-1; CRU329; SFB1160; Heisenberg programDeutsche Forschungsgemeinschaft (DFG) SFB 1453; SFB 1479; SFB 1160; SFB/TRR167; SFB/TRR 353; SFB/TRR 359; FOR 5476European Molecular Biology Organization (EMBO) ALTF 927-2013European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) ALTF 84-2011Fondation pour la Recherche Médicale (FRM) ARF20150934110Wilhelm Sander-Stiftung (Wilhelm Sander Foundation) project-ID 2023.010.1
6 · The paper itself

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease. Limited treatment options lead to renal failure in the vast majority of affected individuals. Novel therapeutic approaches are needed. Recent evidence has identified inflammation as an important driver of ADPKD. We analyzed transcriptional profiles in an orthologous Pkd1 mouse model and found a strong upregulation of the inflammasome pathway. To investigate the role of inflammasomes on cyst formation and kidney function, we modulated inflammasome activity through genetic targeting of the essential inflammasome component

Indexed as

InflammasomesPolycystic Kidney, Autosomal DominantAnimalsCARD Signaling Adaptor ProteinsDisease Models, AnimalFuransIndenesInflammationKidneyMiceSulfonamidesSulfonesTRPP Cation ChannelsCARD Signaling Adaptor ProteinsFuransIndenesInflammasomesN-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamidePycard protein, mouseSulfonamidesSulfonesTRPP Cation ChannelsADPKDinflammasomePKD1 mouse model

Identifiers

PMID41231953
PMCPMC12646232

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.