ArticleProceedings of the National Academy of Sciences of the United States of America2025
MARK2 regulates C9orf72 repeat-associated non-AUG translation.
Yu-Ning Lu, Xiangning Li, Lindsey Hayes, Xiao-Feng Zhao, Jiou Wang
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
5 authors.
Yu-Ning LuDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0002-8176-2108 Xiangning LiDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.ORCID 0009-0002-7312-2976 Lindsey HayesBrain Science Institute and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0003-4818-6054 Xiao-Feng ZhaoDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.
Jiou WangDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0001-9115-8708 Funding
Neurodegeneration and Proteotoxicity Dissected in C. elegans and MammalsR01NS074324 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WANG, JIOU · 2011 to 2025
$6.2MInvestigating the role of C9orf72 in autophagic and metabolic dysregulation in ALS/FTDR01NS089616 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Jiou Wang · 2015 to 2026
$6.0MMechanisms of RNA and Protein Dysregulations in ALS/FTD Associated with FUS and Ubiquilin 2R01NS110098 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Jiou Wang · 2019 to 2026
$5.0MMolecular Basis of Pathogenic Cascades in ALS/FTD Initiated from C9orf72 Hexanucleotide Repeat ExpansionR01NS128494 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Jiou Wang · 2022 to 2026
$3.1MNINDS NIH HHS R01 NS074324NINDS NIH HHS R01 NS089616NINDS NIH HHS R01 NS110098NINDS NIH HHS R01 NS128494
6 · The paper itselfAbstract
Protein homeostasis is exquisitely regulated through processes involving protein synthesis essential for cellular health and disease prevention. Repeat-associated non-AUG (RAN) translation at expanded GGGGCC repeats in the
Indexed as
Amyotrophic Lateral SclerosisC9orf72 ProteinProtein BiosynthesisProtein Serine-Threonine KinasesAnimalsDisease Models, AnimalDNA Repeat ExpansionEukaryotic Initiation Factor-2Frontotemporal DementiaHumansMiceNeuronsSignal TransductionC9orf72 ProteinC9orf72 protein, humanEukaryotic Initiation Factor-2Protein Serine-Threonine KinaseseIF2αintegrated stress responseMARK2
Identifiers
PMID41231952
PMCPMC12646204
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