Evidence map›Paper›PMID 41231949›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The function of Mak16 in ribosome biogenesis depends on its [4Fe-4S] cluster.

Nadine Duppe, Lukas Knauer, Marc Hagebölling, Lena Langner, Martin Stümpfig, Volker Schünemann, Antonio J Pierik, Daili J Netz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nadine DuppeDepartment of Chemistry, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Kaiserslautern 67663, Germany.ORCID 0009-0004-4857-0421
Lukas KnauerDepartment of Chemistry, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Kaiserslautern 67663, Germany.ORCID 0009-0000-1839-0412
Marc HageböllingDepartment of Chemistry, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Kaiserslautern 67663, Germany.ORCID 0009-0003-3234-0026
Lena LangnerDepartment of Chemistry, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Kaiserslautern 67663, Germany.ORCID 0009-0009-1122-5946
Martin StümpfigInstitut für Zytobiologie und Zytopathologie, Fachbereich Medizin und Zentrum für Synthetische Mikrobiologie Synmikro, Philipps-Universität Marburg, Marburg 35032, Germany.
Volker SchünemannDepartment of Physics, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Kaiserslautern 67663, Germany.
Antonio J PierikDepartment of Chemistry, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Kaiserslautern 67663, Germany.ORCID 0000-0002-1509-6370
Daili J NetzDepartment of Chemistry, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Kaiserslautern 67663, Germany.ORCID 0000-0001-9535-6963

Funding

Deutsche Forschungsgemeinschaft (DFG) 311771359Deutsche Forschungsgemeinschaft (DFG) 311771384Deutsche Forschungsgemeinschaft (DFG) 389965693Deutsche Forschungsgemeinschaft (DFG) 444947649
6 · The paper itself

Abstract

Mak16 and its interacting partner Rpf1 play a critical role at an early step in the maturation of the ribosomal 60S subunit of eukaryotes, as revealed by cryoelectron microscopy structures. While these studies suggested no metal participation or the presence of a Zn

Indexed as

Cell Cycle ProteinsIron-Sulfur ProteinsOrganelle BiogenesisRibosome Subunits, Large, EukaryoticRNA-Binding ProteinsCell NucleusHydrogen PeroxideMitochondriaOxidation-ReductionOxidative StressProtein StabilityRibosomal ProteinsRNA, RibosomalSaccharomyces cerevisiae ProteinsCell Cycle ProteinsHydrogen PeroxideIron-Sulfur ProteinsMAK16 protein, S cerevisiaeRibosomal ProteinsRNA-Binding ProteinsRNA, RibosomalRNA, ribosomal, 25SRpf1 protein, S cerevisiaeRPL28 protein, humanSaccharomyces cerevisiae Proteinsiron–sulfurmetallocofactorribosome biogenesis

Identifiers

PMID41231949
PMCPMC12646323

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.