In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Ibrahim AldobiyanUCL Respiratory, Division of Medicine and the Institute of Structural and Molecular Biology, University College London, London WC1E 6JF, United Kingdom.ORCID 0000-0002-3426-4405 Emma L K EllistonUCL Respiratory, Division of Medicine and the Institute of Structural and Molecular Biology, University College London, London WC1E 6JF, United Kingdom.
Narinder Heyer-ChauhanUCL Respiratory, Division of Medicine and the Institute of Structural and Molecular Biology, University College London, London WC1E 6JF, United Kingdom.ORCID 0000-0002-3500-9174 Stefan T AroldKing Abdullah University of Science and Technology Center of Excellence for Smart Health, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.ORCID 0000-0001-5278-0668 Lingyun ZhaoImaging and Characterization Core Lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.ORCID 0000-0003-4557-8458 Brandon HuntingtonKing Abdullah University of Science and Technology Center of Excellence for Smart Health, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.ORCID 0000-0001-5601-3917 Sarah M LowenUCL Respiratory, Division of Medicine and the Institute of Structural and Molecular Biology, University College London, London WC1E 6JF, United Kingdom.ORCID 0000-0002-1764-5484 Elena V OrlovaInstitute of Structural and Molecular Biology, School of Natural Sciences, Birkbeck, University of London, London WC1E 7HX, United Kingdom.ORCID 0000-0003-3371-415X James A Irving *UCL Respiratory, Division of Medicine and the Institute of Structural and Molecular Biology, University College London, London WC1E 6JF, United Kingdom.ORCID 0000-0003-3204-6356 David A Lomas *UCL Respiratory, Division of Medicine and the Institute of Structural and Molecular Biology, University College London, London WC1E 6JF, United Kingdom.ORCID 0000-0003-2339-6979 Funding
Alpha-1 Foundation (A1F) 1036784Saudi Arabian Cultural Bureau (SACB) I. AldobiyanUKRI | Medical Research Council (MRC) MR/V034243/1Wellcome Trust
6 · The paper itselfAbstract
Originating 2 to 3 millennia ago in a Scandinavian population, the SERPINA1 Z allele (Glu342Lys) is present in up to 2.5% of populations of Northern European descent and accounts for 95% of severe α
Indexed as
alpha 1-Antitrypsinalpha 1-Antitrypsin DeficiencyLiverProtein Aggregation, PathologicalCryoelectron MicroscopyHumansModels, MolecularProtein Aggregatesalpha 1-AntitrypsinProtein AggregatesSERPINA1 protein, humanconformational pathologydomain swapex vivo structural biologynonamyloidserpin
Identifiers
PMID41231946
PMCPMC12646233
What OpenQuestion holds
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