ArticlePloS one2025
Association between COVID-19 vaccination and atopic diseases in US adults: A retrospective cohort study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COVID-19 Vaccinations are associated with higher allergic reactions risk among adults. However, evidence on whether no vaccinated with COVID-19 vaccine is associated with fewer incidence among individuals with atopic diseases remains limited. This study is to investigate whether COVID-19 Vaccination is associated with increased risk of adult atopic diseases. A cross-sectional survey was conducted using data from the 2021 US National Health Interview Survey (NHIS) that included 29201 respondents aged 18 years or older adults. Multivariable logistic regression was conducted to estimate the association of COVID-19 vaccination and atopic disease. Crude and adjusted odds ratios (aORs) and 95% CIs were estimated. Analysis of the data was performed from October 01, 2023, to January 22, 2024. Of 29201 respondents (mean [SD] age, 52.6 [18.4] years; 13240 [45.3%] male), the US prevalence was 49.6% (unweighted, 95% CI, 49.1%-50.2%) from all years of the2021 NHIS for self-reported hay fever, 13.7% (unweighted,95% CI, 13.3%- 14.1%) for asthma, 10.9% (unweighted, 95% CI,10.1%-11.3%) for skin allergy, 10.0% (unweighted,95% CI, 9.7%-10.4%) for food allergy, and 45.1% (unweighted,95% CI, 45.6%-45.7%) for no COVID-19 vaccination, 6.4% (95% CI, 6.1%-6.9%) for one COVID-19 vaccination, 43.1% (unweighted, 95% CI, 42.6%-43.7%) for two COVID-19 vaccinations, 5.3% (unweighted, 95% CI, 5.1%-5.6%) for more than 2 COVID-19 vaccinations. In multivariable analysis across the 2021 NHIS, COVID-19 vaccinations does not increase the risk of skin allergy(aOR, 1.03;95%CI, 0.86-1.28; P = 0.135), asthma (aOR, 1.05;95%CI,0.98-1.13; P = 0.164), and food allergy (aOR, 1.03;95%CI, 0.95-1.12; P = 0.437) in adults, compared with adults without COVID-19 vaccination; whereas, in patients with COVID-19 vaccination had significantly higher odds of hay fever (aOR, 1.21;95% CI, 1.15-1.27;P < 0.001) compared with adults without COVID-19 vaccination. Further sensitivity and subgroup analysis suggested that the number of COVID-19 vaccinations was associated with newly diagnosed hay fever (aOR, 1.17 95% CI,1.10-1.24; P < 0.001) and asthma (aOR, 1.12 95% CI,1.03-1.27; P = 0.011). In this cross-sectional study, COVID-19 vaccination was associated with higher risk incidence of hay fever, but COVID-19 vaccination was not associated with an increased in incidence risk in skin allergy, asthma and food allergy. The determinants of the association of COVID-19 vaccination with atopic diseases should be identified in the future studies are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.