ArticleMedical physics2025
Measurement of microdosimetric spectra of high-LET particle beams using the ENCORE detector.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A standardized measurement-based approach to estimate modelled relative biological effectiveness for auditing carbon ion beams.Physics and imaging in radiation oncology · 2026Article
- Measurement of microdosimetric spectra of high-LET particle beams using the ENCORE detector.Medical physics · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeavy ion radiotherapy offers distinct advantages over conventional treatments due to its superior dose distribution and enhanced biological effectiveness. However, the microdosimetric characteristics of high linear energy transfer (LET) ions, particularly near the Bragg peak, remain poorly characterized. Most experimental microdosimetry has been conducted at lower LETs, leaving a critical gap in high-LET microdosimetric data. PURPOSE: This study aims to extend microdosimetry to several different high-LET ions (700-2500 keV/µm) using the novel ENCORE detector.
methodsMicrodosimetry was performed at the Florida State University John D. Fox Accelerator Laboratory using the ENCORE detector, a multi-sampling ionization chamber filled with low-pressure tissue-equivalent gas capable of resolving energy deposition from approximately 200 keV to 3 MeV.
resultsThe 16 strips of the ENCORE corresponded to a tissue-equivalent thickness of 17.6 µm, enabling resolution of energy deposition immediately proximal and distal to the Bragg peak. In six measurement configurations, the ion beam stopped within this range, allowing precise mapping of the
conclusionThis study demonstrated that ENCORE can resolve microdosimetric spectra with high spatial and LET resolution across a range of ion energies. Measured
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