Evidence map›Paper›PMID 41231675›Full record

ArticleAnalytical chemistry2025

Interrogation of Small Molecules to Surface-Bound Aptamer Binding Kinetics with Electrochemical Aptamer-Based Sensors Using Intermittent Pulse Amperometry.

Sanduni W Abeykoon, Warunika N Dikella, Mirelis Santos-Cancel, Robert A Lazenby, Ryan J White

Abstract read
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In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sanduni W AbeykoonDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221-0172, United States.
Warunika N DikellaDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221-0172, United States.
Mirelis Santos-CancelDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221-0172, United States.
Robert A LazenbyDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221-0172, United States.ORCID 0000-0002-3622-4108
Ryan J WhiteDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221-0172, United States.ORCID 0000-0003-0849-0457

Funding

Developing Electrochemical Sensors to Enable Quantitative Measure of Gliotransmitter Release from AstrocytesR01NS134365 · NINDS · UNIVERSITY OF CINCINNATI · PI Ryan J. White, Yi Xiao · 2023 to 2026
$1.5M
Aptamer-Hydrogel Hybrid Sensors for Continuous Therapeutic Drug MonitoringR01GM117159 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI WHITE, RYAN J. · 2016 to 2020
$1.2M
NIGMS NIH HHS R01 GM117159NINDS NIH HHS R01 NS134365
6 · The paper itself

Abstract

Structure-switching electrochemical-aptamer-based (E-AB) sensors are a group of chemical sensors that allow specific target recognition of biological molecules with high sensitivity. In this article, intermittent pulse amperometry (IPA) is utilized to perform millisecond-resolved interrogation of E-AB sensors to monitor binding kinetics of small-molecule target analyte binding to surface-tethered DNA aptamers. To achieve this goal, the E-AB sensor platform is coupled with a flow injection analysis system that permits the determination of observed binding rate (

Indexed as

Aptamers, NucleotideBiosensing TechniquesElectrochemical TechniquesTobramycinElectrodesKineticsSurface Plasmon ResonanceSurface PropertiesAptamers, NucleotideTobramycin

Identifiers

PMID41231675
PMCPMC13101946

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.