Evidence map›Paper›PMID 41231419›Full record

ArticleInternational ophthalmology2025

The urinary 6-sulfatoxymelatonin level in patients with central serous chorioretinopathy and its correlation with choroidal vasculature.

Kun Xu, Yue Xu, Zhonghua Luo, Qinmeng Shu, Lingyi Li, Jicheng Lin, Fengmei Yang, Ching-Kit Tsui, Xiaoyu Tang, Peiqi Wu and 3 more

Abstract read
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In one paragraph

Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Kun Xu *State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China.
Yue Xu *State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China.
Zhonghua Luo *State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China.
Qinmeng ShuEye Institute, Eye and ENT Hospital, College of Medicine, Fudan University, Shanghai, Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, National Health Commission, Shanghai, China.
Lingyi LiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China.
Jicheng LinState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China.
Fengmei YangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China.
Ching-Kit TsuiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China.
Xiaoyu TangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China.
Peiqi WuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China.
Haolin KongState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China.
Shanshan YuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China. yushsh8@mail.sysu.edu.cn.
Xiaoling LiangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China. liangxlsums@qq.com.

Funding

Guangdong Basic and Applied Basic Research Foundation Grant No. 2022A1515010355Research Grant from Guangzhou Municipal Science and Technology Bureau in China Grant No. 202102010324
6 · The paper itself

Abstract

purposeTo investigate the changes in melatonin secretion levels and its association with choroidal vasculature parameters in patients with central serous chorioretinopathy (CSC).

methodsIn this study, 30 male patients were enrolled diagnosed with CSC and 30 healthy male controls. The choroidal vasculature system of all participants were assessed using ultra-widefield swept-source optical coherence tomography angiography (UWF-SS-OCTA). Specifically, we measured choroidal vascular volume (CVV), choroidal vascularity index (CVI), and choroidal thickness (CT). Additionally, the levels of urinary 6-sulfatoxymelatonin(6-SMT) in participants were determined using enzyme-linked immunosorbent assay. Finally, the correlations between normalized 6-SMT and choroidal vascular parameters were evaluated in CSC and controls.

resultsThe levels of urinary normalized 6-SMT in CSC patients (24.8, 20.2 - 28.1) were significantly lower than the control group (36.1, 30.0 - 45.2, P < 0.001). Compared with the control group, CSC patients exhibited significantly larger average CVV, CVI, and CT (CVV: 44.6 ± 8.9 mm

conclusionThis study found that CSC patients had lower levels of urinary 6-SMT. The concentration of 6-SMT was associated with choroidal vasculature parameters. The decrease in melatonin secretion might be a risk factor for CSC.

Indexed as

Central Serous ChorioretinopathyChoroidMelatoninAdultBiomarkersEnzyme-Linked Immunosorbent AssayFluorescein AngiographyFundus OculiHumansMaleMiddle AgedTomography, Optical Coherence6-sulfatoxymelatoninBiomarkersMelatoninCentral serous chorioretinopathyChoroidal vasculatureMelatoninOptical coherence tomography angiography

Identifiers

PMID41231419

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