Observational studyJournal of assisted reproduction and genetics2026
Impact of Follicle Size at Trigger on Reproductive Outcomes in Letrozole-Modified Natural Frozen Embryo Transfer Cycles in High Responder Patients.
Observational study in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate whether follicle size at hCG trigger influences reproductive outcomes in letrozole-modified natural frozen embryo transfer (let-mNC-FET) cycles among high-responder patients.
methodsThis observational cohort included 170 let-mNC-FET cycles. Patients were stratified by follicle-size percentiles at trigger: 0-25th (15-17 mm; n = 43), 25-75th (18-20 mm; n = 90), and > 75th (21-24 mm; n = 37). Oral dydrogesterone provided luteal support. Serum progesterone (P4) on embryo-transfer (ET) day was measured with an assay that does not detect dydrogesterone (reflecting endogenous luteal production). The primary outcome was the ongoing pregnancy rate (OPR). Group comparisons used ANOVA/Kruskal-Wallis and χ
resultsPositive hCG and OPR did not differ across percentile groups (51.2%, 52.2%, 55.6%; p = 0.920 and 48.8%, 50.0%, 52.7%; p = 0.833, respectively). Endometrial thickness at trigger differed by group (medians 8.0, 9.0, 7.8 mm; p < 0.001), while ET-day P4 increased with larger follicles (medians 19.74, 21.00, 26.50 ng/mL; p = 0.001; post-hoc 0-25th vs > 75th p = 0.0009). In multivariable analysis, younger age (aOR 0.834; 95% CI 0.762-0.914; p = 0.0001), higher BMI (aOR 1.169; 1.015-1.346; p = 0.0303), fewer stimulation days (aOR 0.798; 0.647-0.983; p = 0.0343), larger leading follicle size (aOR 1.343; 1.059-1.703; p = 0.0151), and higher ET-day P4 (aOR 1.067; 1.027-1.108; p = 0.0007) independently predicted OPR; EMT and AMH were not associated (p ≥ 0.08 and p = 0.25).
conclusionsAlthough OPR did not differ across follicle-size strata, larger follicle size at trigger and higher endogenous luteal P4 were independent predictors of OPR in highresponders. Confirmation in adequately powered prospective studies is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.