Evidence map›Paper›PMID 41231379›Full record

ArticleJournal of assisted reproduction and genetics2026

AMHR2 c.-482A > G and serum basal FSH as predictors of ovarian response to stimulation.

Yunlei Cao, Wenjing Zhang, Yupei Shen, Xianliang Huang, Zhaofeng Zhang, Ling Hong, Weiqiang Zhu, Jian Zhang, Jing Du

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yunlei Cao *Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, 200433, China.
Wenjing Zhang *Shanghai Towako Hospital, Shanghai, 200131, China.
Yupei Shen *Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200032, China.ORCID http://orcid.org/0000-0001-6253-6626
Xianliang HuangShanghai Tianyou Hospital, Shanghai, 200331, China.
Zhaofeng ZhangShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200032, China.
Ling HongShanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China.
Weiqiang ZhuShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200032, China.
Jian ZhangShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200032, China.
Jing DuShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200032, China. dujing42@126.com.ORCID http://orcid.org/0000-0002-6767-2763

Funding

National Natural Science Foundation of China 82771655
6 · The paper itself

Abstract

purposeOvarian stimulation (OS) is a critical component of assisted reproduction techniques (ART), in which gonadotropins are administered to induce follicular development and maturation to improve the chances of conception. It has been reported that ovarian response to OS can be affected by certain genetic factors. This study explores the relationship among SNVs of AMHR2 (c.-482A > G/rs2002555 and c.1749C > T/rs2071558), basal FSH and estradiol levels, gonadotropin dosage, and ovarian response to identify predictive indicators.

methodsOocytes were retrieved from 684 infertile Chinese women treated with ART. All patients were divided into three groups: low (< 6 oocytes), normal (6-14 oocytes), high response (> 14 oocytes). Genotyping of c.-482A > G and c.1749C > T were detected on the Sequenom iPlexMassARRAY platform. Transcriptional function of c.-482A > G variant in AMHR2 promoter was validated by Luciferase Reporter Assay in 293 T cells.

resultsOur results indicated that both c.-482A > G and c.1749C > T SNVs were associated with basal FSH levels (p = 0.047 and 0.023, respectively). Genotype and allele distribution frequencies of AMHR2 c.-482A > G were significantly different among the three ovarian response groups (p = 0.007 and 0.009, respectively). AMHR2 c.-482A > G was associated with the number of total oocytes retrieved (p = 0.011). FSH was associated with the ovarian response (p < 0.001). Validation by Luciferase Assay indicated AMHR2 c.-482A > G mutation in the promoter region affect the promoter activity.

conclusionAMHR2 c.-482A > G SNVs may be involved in the mechanism of the ovarian response to OS. AMHR2 c.-482A > G SNVs can interact with basal FSH levels, and jointly serve as predictor of the ovarian response to OS.

Indexed as

Follicle Stimulating HormoneInfertility, FemaleOvulation InductionAdultAnti-Mullerian HormoneEstradiolFemaleFertilization in VitroGenotypeHumansOocytesOvaryPolymorphism, Single NucleotideReceptors, PeptideReceptors, Transforming Growth Factor betaAnti-Mullerian Hormoneanti-Mullerian hormone receptorEstradiolFollicle Stimulating HormoneReceptors, PeptideReceptors, Transforming Growth Factor betaAMHR receptor 2FSH levelOvarian responseOvarian stimulationVariants

Identifiers

PMID41231379
PMCPMC12901770

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.