ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2026
Comparison of transjugular and transfemoral approaches for leadless pacemaker implantation in Asian patients: an exploratory study.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Cerebral air embolism after implantation of a leadless pacemaker via the right internal jugular vein: a case report.European heart journal. Case reports · 2026Article
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9 authors.
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Abstract
backgroundThe transjugular approach has recently gained attention as a viable alternative for leadless pacemaker implantation. However, clinical data in Asian populations, who often present with smaller body size and vascular anatomy, remain limited. This study aimed to evaluate the safety and efficacy of the transjugular approach compared with the conventional transfemoral route in an Asian cohort.
methodsWe retrospectively analyzed 112 patients who underwent leadless pacemaker implantation between March 2021 and June 2025 at a single center. Patients were categorized by access route: transfemoral (n = 81) or transjugular (n = 31). Baseline characteristics, pacing parameters, and peri-procedural complications were compared between groups.
resultsBaseline demographics and device indications were similar between groups. Procedural success, fluoroscopy time, and pacing performance were also comparable. However, puncture site bleeding complications occurred exclusively in the transfemoral group (14.8% vs. 0.0%, P = 0.035), and procedure-to-discharge time was significantly shorter in the transjugular group (1.4 ± 0.6 vs. 2.2 ± 1.4 days, P = 0.008). In multivariate analysis, female sex was identified as a significant independent predictor of procedure-related overall bleeding, while the transjugular approach was significantly protective (odds ratio 0.11, 95% confidence interval: 0.01-0.94, P = 0.043). No major bleeding events requiring surgical or endovascular intervention, device dislodgement, or procedure-related death occurred in the transjugular group.
conclusionThe transjugular approach for leadless pacemaker implantation demonstrated comparable procedural efficacy and pacing performance, with significantly lower rates of both puncture site bleeding and overall complications, as well as shorter hospitalization. These findings support its use as a safe and effective alternative access route, particularly in Asian patients.
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