ArticleJournal of cell science2025
Vinculin Y822 phosphorylation regulates adhesion remodeling during cardiomyocyte maturation.
Article in Journal of cell science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- ABL kinases regulate FGF signaling independent of CRK phosphorylation to prevent Peters anomaly type II.Nature communications · 2026Article
- Elucidating Gene Functions in Congenital Heart Disease.Current treatment options in cardiovascular medicine · 2026Review
- E-Cadherin: A conductor of cellular signaling.Current opinion in cell biology · 2025Review
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10 authors.
Funding
Abstract
In the heart, cardiomyocyte cell-matrix and cell-cell adhesions reorganize in response to increased cardiac demand and growth. Vinculin (VCL), a mechanosensitive adaptor protein, links filamentous actin to cell-matrix and cell-cell adhesions. Yet how VCL regulates remodeling of the two adhesion systems is poorly understood. Here, we investigate the role of phosphorylation at VCL tyrosine residue 822 (pY822) in cardiomyocyte adhesion and heart function. VCL Y822 phosphorylation levels peaked during adhesion remodeling in the developing heart and were reduced as adhesions matured postnatally. VCL pY822 levels also increased in the adult heart following injury. We mutated Vcl Y822 to phenylalanine (Y822F) in the mouse to determine the in vivo function of pY822. Homozygous mutant Vcl Y822F mice were viable but exhibited cardiac dysfunction at 28 weeks. We found that VCL pY822 regulated cardiomyocyte cell-matrix and cell-cell adhesions during postnatal heart development. Defects in cell-cell adhesion organization were also observed in cultured Vcl Y822F cardiomyocytes. Our results demonstrate that VCL Y822 phosphorylation regulates adhesion organization in cardiomyocytes, highlighting the importance of post-translational modification in modulating VCL function in the heart.
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