Effect of some prostanoid receptor modulators on cholinergic and purinergic pathways in rat model of hemorrhagic cystitis: potential beneficial action of selexipag and alprostadil.

Evelyn M Gerges, Mai M Helmy, Tahia T Daabees, Amira M Senbel

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Evelyn M GergesDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alazarita, 21521, Alexandria, Egypt.

Mai M HelmyDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alazarita, 21521, Alexandria, Egypt. mai.helmy@alexu.edu.eg.

Tahia T DaabeesDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alazarita, 21521, Alexandria, Egypt.

Amira M SenbelBiological and Clinical Sciences Division, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, Alexandria, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetylcholine (ACh) and adenosine triphosphate (ATP) are the major neurotransmitters in bladder contraction. This study investigates the modulatory role of some prostanoids in cholinergic and purinergic pathways in normal and cystitis. Cystitis was induced in rats by cyclophosphamide single injection (300 mg/kg) and confirmed histopathologically. Organ bath experiments were implemented using isolated detrusor muscles. Bladder contraction was induced by electrical stimulation and by ACh or ATP direct addition. Cystitis attenuated bladder contractility. Alprostadil and selexipag amplified neurogenic and cholinergic contractions in normal and inflamed bladder. The neurogenic contractions amplification was higher in cystitis with 54.63 ± 42.11% compared to 18.77 ± 5.98% in normal at 10

Indexed as

AcetamidesAlprostadilCystitisPyrazinesReceptors, PurinergicAcetylcholineAdenosine TriphosphateAnimalsCyclophosphamideCystitis, HemorrhagicDisease Models, AnimalFemaleMaleMuscle ContractionRatsRats, WistarAcetamidesAcetylcholineAdenosine TriphosphateAlprostadilCyclophosphamidePyrazinesReceptors, PurinergicselexipagAlprostadilDetrusor muscleHemorrhagic cystitisProstanoidSelexipag

Identifiers

PMID41231277

DOI10.1007/s00210-025-04632-8

PMCPMC13046702

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.