ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2025
Oxidative environments promote the formation of detergent-resistant IgG aggregates mediated by Cu(II) assessed by optical density: implications in vivo.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Protein proclivity to aggregation leads to the formation of insoluble aggregates which slowly build up over the years within blood and different tissues. In humans, the content of these detergent resistant aggregates has been found increased in elder subjects compared to younger ones. The aggregation process is driven not solely by the presence of prone to aggregation proteins but by pro-aggregating agents such as Cu(II) which promotes the aggregation of IgG among others. Cu(II) and Zn(II) induce IgG reversible aggregates. However, co-incubation of Cu(II) with hydrogen peroxide (H
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