Evidence map›Paper›PMID 41231265›Full record

ArticleInternational journal of colorectal disease2025

International expert Delphi consensus on management of early and locally advanced rectal cancer.

Cihad Tatar, Tayfun Bisgin, Aras Emre Canda, Feza Karakayali, Ethem Gecim, Ali Cihat Yildirim, Erdinc Cetinkaya, Ibrahim Ethem Cakcak, Ibrahim H Ozata, Mehmet Ali Koc and 6 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of colorectal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Cihad TatarDepartment of Surgery, Acıbadem Taksim Hospital, Istanbul, Turkey. tatarcihad@gmail.com.
Tayfun BisginDepartment of Surgery, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
Aras Emre CandaDepartment of Surgery, KRC Clinic for Colorectal Surgery and Peritoneal Surface Malignancies, Izmir, Turkey.
Feza KarakayaliDepartment of Surgery, School of Medicine, Baskent University, Istanbul, Turkey.
Ethem GecimDepartment of Surgery, School of Medicine, Ankara University, Ankara, Turkey.
Ali Cihat YildirimDepartment of Surgery, School of Medicine, Kutahya Health Sciences University, Kutahya, Turkey.
Erdinc CetinkayaDepartment of Surgery, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey.
Ibrahim Ethem CakcakDepartment of Surgery, School of Medicine, Trakya University, Edirne, Turkey.
Ibrahim H OzataDepartment of Surgery, School of Medicine, Koc University, Istanbul, Turkey.
Mehmet Ali KocDepartment of Surgery, School of Medicine, Ankara University, Ankara, Turkey.
Huseyin Onur AydinDepartment of Surgery, School of Medicine, Baskent University, Istanbul, Turkey.
Osman BozbiyikDepartment of Surgery, School of Medicine, Ege University, Izmir, Turkey.
Ramazan KozanDepartment of Surgery, School of Medicine, Gazi University, Ankara, Turkey.
Yusuf SevimDepartment of Surgery, School of Medicine, University of Health Sciences, Kayseri, Turkey.
Ilknur Erenler BayraktarDepartment of Surgery, Memorial Sisli Hospital, Istanbul, Turkey.
TSCRS Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTreatment strategies for early and locally advanced rectal cancer are evolving, particularly with the increasing use of non-operative management and multidisciplinary decision-making. The aim of this study is to establish an expert-based consensus on the preferred treatment strategies for early and locally advanced rectal cancer.

methodsA 12-member steering committee was established to conduct a modified Delphi consensus process on rectal cancer management. The committee performed a systematic literature review (2014-2024) to inform survey development. A 49-question survey, including open-ended and multiple-choice items, was developed and refined. A panel of 44 colorectal surgery experts was selected based on academic contributions, and two Delphi rounds were conducted anonymously. Consensus was defined as ≥ 70% agreement. Based on panel responses, 29 consensus statements were formulated.

resultsThe panel reached consensus on the importance of multidisciplinary evaluation and surgical expertise in total mesorectal excision. Structured MRI reporting was recommended. Total neoadjuvant therapy was preferred for high-risk tumors. Non-operative management was recommended in cases of clinical complete response, with defined surveillance strategies. The role of biopsy in near-complete responders was also addressed.

conclusionsThis international consensus provides structured guidance on the management of rectal cancer, emphasizing multidisciplinary planning, the role of total neoadjuvant therapy in organ preservation, and rigorous surveillance protocols in non-operative management. These recommendations aim to standardize care and support evidence-informed clinical decision-making.

Indexed as

Delphi TechniqueInternationalityRectal NeoplasmsHumansNeoadjuvant TherapyNeoplasm StagingClinical complete responseConsensusMultidisciplinary teamNon-operative managementRectal cancerTotal neoadjuvant therapy

Identifiers

PMID41231265
PMCPMC12615519

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.