Evidence map›Paper›PMID 41231259›Full record

ArticleCell and tissue research2025

Fibulin-4 is required for the mechanical stability of tendons.

Takako Sasaki, Kyoko Jin, Aki Takimoto, Yuki Taga, Yoshihiro Ishikawa, Hans Peter Bächinger, Takao Sakai, Takeshi Terabayashi, Katsuhiro Hanada, Ursula Schlötzer-Schrehardt and 4 more

Abstract read
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In one paragraph

Article in Cell and tissue research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Takako SasakiDepartment of Biochemistry II, Faculty of Medicine, Oita University, Oita, 879-5593, Japan. tsasaki@oita-u.ac.jp.
Kyoko JinDepartment of Biochemistry II, Faculty of Medicine, Oita University, Oita, 879-5593, Japan.
Aki TakimotoLaboratory of Cellular Differentiation, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, 606-8507, Japan.
Yuki TagaNippi Research Institute of Biomatrix, Ibaraki, 302-0017, Japan.
Yoshihiro IshikawaDepartment of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR, 97239, USA.
Hans Peter BächingerDepartment of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR, 97239, USA.
Takao SakaiDepartment of Diagnostic Pathology, School of Medicine, Fujita Health University, Aichi, 470-1192, Japan.
Takeshi TerabayashiDepartment of Pharmacology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan.
Katsuhiro HanadaClinical Engineering Research Center, Faculty of Medicine, Oita University, Oita, 879-5593, Japan.
Ursula Schlötzer-SchrehardtDepartment of Ophthalmology, University of Erlangen-Nürnberg, 91045, Erlangen, Germany.
Chisa ShukunamiLaboratory of Cellular Differentiation, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, 606-8507, Japan.
Yuji HirakiLaboratory of Cellular Differentiation, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, 606-8507, Japan.
Tomoyuki NakamuraDepartment of Pharmacology, Kansai Medical University, Osaka, 573-1010, Japan.
Ei YamamotoDepartment of Biomedical Engineering, Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama, 649-6433, Japan.

Funding

Japan Society for Promotion and Science 22K09335
6 · The paper itself

Abstract

Fibulin-4, an extracellular matrix protein, is indispensable for elastic fiber assembly. Fibulin-4 null mice show bilateral forelimb contracture and patients with EFEMP2/FBLN4 mutations demonstrate similar defects, besides joint laxity, vascular and pulmonary abnormalities. Here we report that limb tendons in fibulin-4 null mice developed normally until E17.5-18.5, but thereafter　thinner tendons showed abnormalities, suggesting that fibulin-4 maintains the integrity of certain tendons. Tendon/ligament specific conditional knockout mice of Efemp2/Fbln4 (ScxCre-H;Fbln4

Indexed as

Extracellular Matrix ProteinsTendonsAnimalsBiomechanical PhenomenaCells, CulturedCollagenElastinForelimbMiceMice, KnockoutPatellaTenocytesCollagenElastinExtracellular Matrix Proteinsfibulin-4, mouseCollagen fibrillogenesisElastic fiberFibulin-4Mechanical propertyTendon

Identifiers

PMID41231259

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.