Evidence map›Paper›PMID 41231251›Full record

ArticleCellular and molecular life sciences : CMLS2025

Hepatocyte Piezo1 regulates glycogen metabolism via the FGF21-STAT3 pathway.

Tian Tao, Ke Yang, Zhenming Li, Mengyuan Zhang, Zhejiao Zhang, Jinghui Guo, Hui Chen, Geyang Xu

Abstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tian Tao *Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong, 510632, China.
Ke Yang *Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong, 510632, China.
Zhenming LiDepartment of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong, 510632, China.
Mengyuan ZhangDepartment of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong, 510632, China.
Zhejiao ZhangDepartment of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong, 510632, China.
Jinghui GuoSchool of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China.
Hui ChenBiotherapy Center, Cell-gene Therapy Translational Medicine Research Center, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510630, China. chenh567@mail.sysu.edu.cn.
Geyang XuDepartment of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong, 510632, China. xugeyangliang@163.com.ORCID http://orcid.org/0000-0002-5542-1350

Funding

National Natural Science Foundation of China 82170818National Natural Science Foundation of China 82470904National Natural Science Foundation of China 82570987
6 · The paper itself

Abstract

The metabolism of glycogen in the liver plays a crucial role in regulating blood glucose levels. Previous studies have underscored the critical involvement of Piezo1 in glucose metabolism. However, the role of Piezo1 in hepatic glycogen metabolism remain unexplored. We induced liver-specific deletion of Piezo1 in Piezo1

Indexed as

Fibroblast Growth FactorsGlycogenHepatocytesIon ChannelsSTAT3 Transcription FactorAnimalsDiet, High-FatHumansLiverMaleMiceMice, Inbred C57BLMice, KnockoutSignal Transductionfibroblast growth factor 21Fibroblast Growth FactorsGlycogenIon ChannelsPiezo1 protein, mouseStat3 protein, mouseSTAT3 Transcription FactorGYS2Hepatic glycogen metabolismPiezo1PYGL

Identifiers

PMID41231251
PMCPMC12615880

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.