Evidence map›Paper›PMID 41231242›Full record

ArticleCellular and molecular life sciences : CMLS2025

Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4

Camila D Arcuschin, Kamin Kahrizi, Rosalyn W Sayaman, Carolina DiBenedetto, Pedro J Salaberry, Roxana Pirker, Yizhuo Shen, Ons Zakraoui, Cecilia Schwarzer, Alessandro Scapozza and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Camila D Arcuschin *Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina.
Kamin Kahrizi *Department of Pediatrics, Benioff Children's Hospital at Oakland, University of California San Francisco, Oakland, CA, 94609, USA.
Rosalyn W SayamanHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94115, USA.
Carolina DiBenedettoHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94115, USA.
Pedro J SalaberryDepartamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina.
Roxana PirkerHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94115, USA.
Yizhuo ShenDepartment of Pediatrics, Benioff Children's Hospital at Oakland, University of California San Francisco, Oakland, CA, 94609, USA.
Ons ZakraouiDepartment of Pediatrics, Benioff Children's Hospital at Oakland, University of California San Francisco, Oakland, CA, 94609, USA.
Cecilia SchwarzerHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94115, USA.
Alessandro ScapozzaHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94115, USA.
Joseph A CarusoHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94115, USA.
Paola BetancurHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94115, USA.
Julie D SabaDepartment of Pediatrics, Benioff Children's Hospital at Oakland, University of California San Francisco, Oakland, CA, 94609, USA.
Jean-Philippe CoppéHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94115, USA.
Mary-Helen Barcellos-HoffHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94115, USA.
Dietmar KappesFox Chase Cancer Center, Philadelphia, 19111, USA.
Laura van 't VeerHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94115, USA.
Ignacio E SchorDepartamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina. ieschor@fbmc.fcen.uba.ar.
Denise P MuñozDepartment of Pediatrics, Benioff Children's Hospital at Oakland, University of California San Francisco, Oakland, CA, 94609, USA. denise.munoz@ucsf.edu.

Funding

The Cancer Cell Map Initiative v2.0U54CA274502 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$14.2M
Cancer Metabolism Training ProgramT32CA221709 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI David K. Ann, Victoria L. Seewaldt · 2018 to 2026
$1.8M
A systems biology approach to elucidate the biology of immune-associated outcomes in breast cancerK01CA279498 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Rosalyn Wong Sayaman · 2023 to 2026
$696k
Epigenetic role of AID in the epithelial-mesenchymal transition in breast cancerK22CA163969 · NCI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI MUNOZ, DENISE PAULA · 2011 to 2013
$482k
NCI NIH HHS K01 CA279498NCI NIH HHS K22 CA163969NCI NIH HHS T32 CA221709NCI NIH HHS U54 CA274502NIH/NCI 5K22CA163969NIH/NCI K01CA279498NIH/NCI T32CA221709]
6 · The paper itself

Abstract

Despite efforts to understand breast cancer biology, metastatic disease remains a clinical challenge. Identifying suppressors of breast cancer progression and mechanisms of transition to more invasive phenotypes could provide game changing therapeutic opportunities. Transcriptional dysregulation is central to all malignancies, highlighted by the extensive reprogramming of regulatory elements that underlie oncogenic programs. Among these, super-enhancers (SEs) stand out due to their enrichment in genes controlling cancer hallmarks. To reveal novel breast cancer dependencies, we integrated the analysis of the SE landscape with master regulator activity inference for a series of breast cancer cell lines. As a result, we identified T-helper-inducing Poxviruses and Zinc-finger (POZ)/Krüppel-like factor (ThPOK, ZBTB7B), a CD4

Indexed as

Breast NeoplasmsCD4-Positive T-LymphocytesDNA-Binding ProteinsEnhancer Elements, GeneticTranscription FactorsCell LineageCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansPhenotypeDNA-Binding ProteinsTranscription FactorsExtracellular matrixGene regulatory networksPlasticityTranscriptional repressors

Identifiers

PMID41231242
PMCPMC12615902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.