ArticleCerebral cortex (New York, N.Y. : 1991)2025
Mapping along-tract commissural and association white matter microstructural differences in autistic children and young adults.
Article in Cerebral cortex (New York, N.Y. : 1991), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Spatiotemporal white-matter development across early childhood.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- SPECTRA: Spatial Inference for Tractometry Toward Precision Mapping of White Matter Microstructure.bioRxiv : the preprint server for biology · 2026Article
- Tractometry-Based Quantification of Along-Tract White-Matter Hemispheric Asymmetry in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2026Article
- Age-stratified multimodal MRI and machine learning to explore autism-related brain characteristics in youth.Frontiers in psychiatry · 2026Article
- Neurodevelopmental disorders in children: the role of MRI in early detection and intervention planning.Frontiers in neuroscience · 2026Review
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Funding
Abstract
Previous diffusion magnetic resonance imaging (dMRI) research has indicated altered white matter microstructure in autism, but the implicated regions are inconsistent across studies. Such prior work has largely used conventional dMRI analysis methods, including the traditional microstructure model, diffusion tensor imaging (DTI). However, these methods are limited in their ability to precisely map microstructural differences and accurately resolve complex fiber configurations. In our study, we investigated white matter microstructure alterations in autism using the refined along-tract analytic approach, BUndle ANalytics (BUAN), with both an advanced microstructure model, the tensor distribution function (TDF) and DTI. We analyzed dMRI data from 365 autistic and neurotypical participants (5 to 24 yr; 34% female) from 10 cohorts to examine commissural and association tracts. Autism was associated with lower fractional anisotropy and higher diffusivity in localized portions of nearly every commissural and association tract examined; these tracts inter-connected a wide range of brain regions, including frontal, temporal, parietal, and occipital regions. Taken together, BUAN and TDF allow robust and spatially precise mapping of microstructural properties in autism. Our findings rigorously demonstrate that white matter microstructure alterations in autism may be greater within specific regions of individual tracts, and that the implicated tracts are distributed across the brain.
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