Evidence map›Paper›PMID 41231209›Full record

ReviewThe Journal of physiology2026

Piezo1 in intestinal smooth muscle cells: Emerging perspectives.

Geoanna M Bautista, L Fernando Santana, Martin G Martin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Smooth muscle contractile cytoskeleton in health and disease.Journal of muscle research and cell motility · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Geoanna M BautistaDepartment of Pediatrics, University of California Davis Children's Hospital, Sacramento, CA, USA.ORCID 0000-0003-0245-9272
L Fernando SantanaDepartment of Physiology and Membrane Biology, University of California Davis, Davis, CA, USA.ORCID 0000-0002-4297-8029
Martin G MartinDepartment of Pediatrics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-7192-0504

Funding

Piezo-1 & 2’s role in murine intestinal muscularis cells of the SIP syncytiumR01DK132319 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James C Dunn, MARTIN G MARTIN · 2023 to 2026
$2.9M
Smooth Muscle Mechanotransduction: Calcium Dynamics in the Developing GutK08DK143334 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Geoanna Marie Bautista · 2025 to 2026
$329k
NIDDK NIH HHS 1K08DK143334-01NIDDK NIH HHS K08 DK143334NIDDK NIH HHS R01 DK132319NIDDK NIH HHS R01DK132319The Hartwell Foundation A24-0129
6 · The paper itself

Abstract

Intestinal motility is modulated by mechanical forces acting on smooth muscle (e.g. stretch, wall tension), yet the smooth muscle mechanotransduction machinery remains incompletely defined. In this conceptual review we discuss the impact of Piezo1, a mechanosensitive ion channel, on the function of intestinal smooth muscle cells and the regulation of gut motility. This is important as recent work has revealed significant impairments in small bowel contractility, tissue mechanics and structural properties resulting from Piezo1 deletion. Interestingly a large fraction of Piezo1 localizes intracellularly in small bowel smooth muscle cells, in close association with the sarcoplasmic reticulum ryanodine and IP

Indexed as

Ion ChannelsMuscle, SmoothMyocytes, Smooth MuscleAnimalsGastrointestinal MotilityHumansMechanotransduction, CellularMuscle ContractionIon ChannelsPIEZO1 protein, humanintestinal motilityion channelmechanotransductionPiezo1smooth muscle cell physiology

Identifiers

PMID41231209
PMCPMC12783945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.