Evidence map›Paper›PMID 41231185›Full record

ArticleJACC. Clinical electrophysiology2026

Inferior Sino-Atrial Node Exit Sites Are Associated With Electrical Remodeling.

Jiahao Zheng, Mathijs S van Schie, Lixia Dai, Paul Knops, Jolanda Kluin, Yannick J H J Taverne, Vadim V Fedorov, Natasja M S de Groot

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Clinical electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiahao ZhengDepartment of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Mathijs S van SchieDepartment of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Lixia DaiDepartment of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Paul KnopsDepartment of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Jolanda KluinDepartment of Cardiothoracic surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Yannick J H J TaverneDepartment of Cardiothoracic surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Vadim V FedorovBob and Corrine Frick Center for Heart Failure and Arrhythmia, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Natasja M S de GrootDepartment of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Microelectronics, Signal Processing Systems, Faculty of Electrical Engineering, Mathematics and Computer Sciences, Delft University of Technology, Delft, the Netherlands. Electronic address: n.m.s.degroot@erasmusmc.nl.

Funding

Targeting the Arrhythmogenic Sources of Human Atrial FibrillationR01HL135109 · NHLBI · OHIO STATE UNIVERSITY · PI Vadim V Fedorov · 2017 to 2026
$6.0M
Integration of structure and signaling in cardiac pacemaker functionR01HL115580 · NHLBI · OHIO STATE UNIVERSITY · PI FEDOROV, VADIM V · 2013 to 2021
$4.2M
NHLBI NIH HHS R01 HL115580NHLBI NIH HHS R01 HL135109
6 · The paper itself

Abstract

backgroundElectrical activity from the sino-atrial node (SAN) spreads via specific pathways into surrounding atrial tissue. Inferior sino-atrial node exit sites (SAN

objectivesThis study sought to examine differences in unipolar potential morphology and the degree of remodeling at the right atrium (RA) between patients with superior sino-atrial node exit sites (SAN

methodsHigh-resolution epicardial mapping was performed in 27 patients with structural heart disease undergoing elective open-heart surgery. Electrodes within an 8-mm radius of the SAN exit site were classified as the SAN area. Electrophysiological properties, including potential voltage, conduction block, and R/S ratios, were computed.

resultsSAN

conclusionsSAN

Indexed as

Atrial RemodelingSinoatrial NodeAgedAtrial FibrillationEpicardial MappingFemaleHeart AtriaHeart Conduction SystemHumansMaleMiddle Agedelectrophysiologyepicardium mappingright atrium remodelingsino-atrial conduction pathwaysino-atrial node

Identifiers

PMID41231185
PMCPMC12871763

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.