ArticleAngewandte Chemie (International ed. in English)2026
Charge-Driven Self-Assembly of Cholesterol Surfactants into Biofunctional Nanodiscs with Antiviral Activity.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Supramolecular Polymer-Surfactant Co-Assemblies for Multivalent HSV-1 Inhibition.Angewandte Chemie (International ed. in English) · 2026Article
- Charge-Driven Self-Assembly of Cholesterol Surfactants into Biofunctional Nanodiscs with Antiviral Activity.Angewandte Chemie (International ed. in English) · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Self-assembly of lipid structures derived from amphiphilic molecules plays a crucial role in the development of biomimetic systems. Here we report a modular synthetic strategy for developing cholesteryl-oligo-glycerol-based surfactants with tunable head group functionalities ranging from nonionic to anionic. This approach enables the systematic incorporation of functional groups and thus precise control of surface charge and hydrophilicity. To investigate the influence of multivalent charges on supermolecular-assembly behavior, we compared three structurally cholesterol (CL) related surfactants: CL-4S, with four sulfate groups, CL-1S, with a single sulfate group, and CL-4OH, a nonionic analog with four hydroxyl groups. We then incorporated these surfactants into lipid bilayers of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and cholesterol (CL) to study their behavior in membrane-like environments. Experimental, simulation, and theoretical studies demonstrated that the CL-4S formulation was able to convert lipid vesicles into nanodiscs, unlike CL-1S and CL-4OH, demonstrating the importance of adequate charges in supramolecular transition. Furthermore, both 1S-Vesicles (CL-1S based sulfated vesicles) and 4S-Nanodiscs (CL-4S based sulfated nanodiscs) showed inhibitory activity against herpes simplex virus-1 (HSV-1), indicating the potential of this multivalent supramolecular platform for antiviral applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.