ArticleAnnals of medicine2025
Association of CXCL16 in aseptic loosening following total hip arthroplasty and its effect on bone metabolism: a case-control study.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAseptic loosening commonly leads to surgical failure and revision arthroplasty after total hip arthroplasty (THA). C-X-C motif chemokine ligand 16 (CXCL16), a chemokine involved in various inflammatory and immune responses, has been implicated in bone metabolism. This single-institution study investigated the association between CXCL16 and aseptic loosening following THA.
methodsWe compared 100 patients who underwent revision THA due to aseptic loosening (experimental group) to 100 patients who underwent primary THA for femoral neck fracture or congenital hip dysplasia (control group). Immunohistochemistry and RT-PCR were used to assess CXCL16 expression at the protein and mRNA levels. Double immunofluorescence staining determined the RANKL/OPG ratio in periarticular synovial tissues. Statistical analysis included a chi-square test for CXCL16 protein expression differences and Pearson correlation for the relationship between CXCL16 mRNA expression and RANKL/OPG.
resultsProteomics analysis revealed significantly higher CXCL16 expression in the experimental group compared to the control group (
conclusionOur findings reveal a significant association between elevated CXCL16 expression and an increased RANKL/OPG ratio in periprosthetic synovial tissues, suggesting a role for CXCL16 in promoting osteoclast differentiation and activity. These findings offer preliminary insights into CXCL16 as a biomarker and a potential therapeutic target for managing bone resorption in aseptic loosening.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.