Evidence map›Paper›PMID 41231011›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2026

Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease.

Marta Camacho, Julia C Greenland, Alexander R D Peattie, Lennart R B Spindler, Jonathan Holbrook, Lakmini Kahanawita, Tim D Fryer, Young T Hong, Caroline H Williams-Gray

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marta CamachoDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-1490-5703
Julia C GreenlandDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Alexander R D PeattieDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Lennart R B SpindlerDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Jonathan HolbrookDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Lakmini KahanawitaDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Tim D FryerDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Young T HongDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Caroline H Williams-GrayDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-2648-9743

Funding

Cambridge Centre for Parkinson-Plus RG95450Cure Parkinson's Trust G103247Medical Research Council MR/R007446/1Medical Research Council MR/W029235/1NIHR Cambridge Biomedical Research Centre NIHR203312
6 · The paper itself

Abstract

backgroundConstipation is a risk factor for the onset and accelerated progression of Parkinson's disease (PD), but the mechanisms underlying this association are unknown. Neuroinflammation in PD has been demonstrated in postmortem and neuroimaging studies; however, its relationship with constipation has not been investigated.

methodsWe used

resultsHigher GIDS-PD constipation scores were associated with

conclusionsConstipation in early PD is associated with widespread neuroinflammation, suggesting a possible mechanism underlying the association between constipation and faster PD progression. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

BrainConstipationNeuroinflammatory DiseasesParkinson DiseaseAgedDisease ProgressionFemaleHumansMaleMiddle AgedPositron-Emission TomographyconstipationinflammationParkinson's diseasePET imaging

Identifiers

PMID41231011
PMCPMC12951264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.