Evidence map›Paper›PMID 41230968›Full record

ArticlemBio2025

EPR spectroscopy reveals antioxidant manganese defenses in the Lyme disease pathogen

Andrés F Londoño, Ajay Sharma, Venkatesan Kathiresan, Jared Sealy, Robert P Volpe, Cene Gostinčar, Utpal Pal, J Stephen Dumler, Brian M Hoffman, Michael J Daly

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. TheInfection and immunity · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrés F Londoño *School of Medicine, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland, USA.ORCID 0000-0002-4703-1387
Ajay Sharma *Department of Chemistry, Northwestern University, Evanston, Illinois, USA.ORCID 0000-0002-0829-6753
Venkatesan KathiresanDepartment of Chemistry, Northwestern University, Evanston, Illinois, USA.ORCID 0000-0002-4151-9154
Jared SealySchool of Medicine, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland, USA.
Robert P VolpeSchool of Medicine, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland, USA.
Cene GostinčarDepartment of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.ORCID 0000-0002-0149-3674
Utpal PalDepartment of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.ORCID 0000-0002-7504-4628
J Stephen DumlerSchool of Medicine, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland, USA.ORCID 0000-0002-8476-1311
Brian M HoffmanDepartment of Chemistry, Northwestern University, Evanston, Illinois, USA.ORCID 0000-0002-3100-0746
Michael J DalySchool of Medicine, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland, USA.ORCID 0000-0003-1496-5930

Funding

Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig, UTPAL PAL · 2018 to 2026
$13.5M
Coboglobins-Cobalt-Substituted Hemoglobins and MyoglobinR01GM111097 · NIGMS · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 2014 to 2025
$6.7M
BORRELIA GENE PRODUCTS CRITICAL FOR NATURAL INFECTION CYCLER01AI080615 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2009 to 2024
$5.2M
Congressionally Directed Medical Research Programs TB180110Defense Threat Reduction Agency HDTRA1620354Javna Agencija za Raziskovalno Dejavnost RS J4-60078NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI080615NIGMS NIH HHS R01 GM111097
6 · The paper itself

Abstract

Oxidative stress defense in aerobic bacteria relies on Mn-superoxide dismutase (MnSOD) and antioxidant Mn-metabolite complexes (H-Mn) to quench superoxide radicals (O

Indexed as

AntioxidantsBorrelia burgdorferiManganeseElectron Spin Resonance SpectroscopyLyme DiseaseOxidative StressSuperoxide DismutaseSuperoxidesAntioxidantsManganeseSuperoxide DismutaseSuperoxidesBacillusBorreliaDeinococcusENDOREPRionizing radiationLactobacillusmetabolite transportMn-antioxidantMnSODMn speciationMn toxicityROS

Identifiers

PMID41230968
PMCPMC12691683

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.