Evidence map›Paper›PMID 41230964›Full record

ArticleMicrobiology spectrum2026

New insight into the epidemiological trends of respiratory syncytial virus infection and the underlying anti-respiratory syncytial virus mechanisms of andrographolide: integrating Global Burden of Disease database, network pharmacological analysis, and

Lianzhan Huang, Buliduhong Halihaman, Yiyue Han, Jieru Zhou, Changjiang Liu, Haoxue Bai, Xuansheng Ding

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lianzhan Huang *School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, China.ORCID 0000-0003-0811-4910
Buliduhong Halihaman *School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, China.
Yiyue Han *School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, China.
Jieru ZhouSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, China.
Changjiang LiuSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, China.
Haoxue BaiSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, China.
Xuansheng DingSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, China.ORCID 0000-0002-5585-9010

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) infection causes severe burdens and harms worldwide every year, lacking specific therapeutic drugs. Andrographolide is a marketed agent, whose antiviral mechanisms between RSV and the host remain unknown. In this report, we first uncover the global disease burdens caused by RSV infection via Global Burden of Disease database analysis to raise public awareness. Results showed that the overall RSV infection mortality and trends decreased globally during 1990-2021, but children and the elderly remained high-risk populations, and the disease burdens are still severe. Then, an

Indexed as

Antiviral AgentsDiterpenesRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsHumansMolecular Docking SimulationNetwork PharmacologyNF-kappa BandrographolideAntiviral AgentsDiterpenesNF-kappa Bandrographolideanti-RSV mechanismsCX3CR1global trends and burdensrespiratory syncytial virusROS/TXNIP/NF-κB pathwayviral adsorption inhibition

Identifiers

PMID41230964
PMCPMC12772385

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.