ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias.
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Reflections on rural community characteristics by an outreach, recruitment, and engagement team.Journal of Alzheimer's disease : JAD · 2026Article
- Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026Review
- From cradle to cortex: An exposome- and equity-centered perspective of neurocognitive aging and dementia risk in the era of climate change.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
68 authors.
Grace C GeorgeCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, UW Hospital and Clinics, Madison, Wisconsin, USA.ORCID 0000-0001-6700-9964
Sarah A KellerCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, UW Hospital and Clinics, Madison, Wisconsin, USA.
Erin AbnerDepartment of Epidemiology, University of Kentucky College of Public Health, Lexington, Kentucky, USA.
Sara AdarDepartments of Epidemiology and Global Public Health, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Michael L AloscoDepartment of Neurology, Boston Medical Center, Boston, Massachusetts, USA.
Liana G ApostolovaIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Kelly BakulskiDepartments of Epidemiology and Global Public Health, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
James R BatemanDepartments of Neurology and Psychiatry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Stuart BattermanDepartment of Global Public Health, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Thomas G BeachDepartment of Pathology, Banner Sun Health Research Institute, Sun City, Arizona, USA.
Barbara B BendlinCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, UW Hospital and Clinics, Madison, Wisconsin, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Tobey J BetthauserCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, UW Hospital and Clinics, Madison, Wisconsin, USA.
James BrewerDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
William BuckinghamCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, UW Hospital and Clinics, Madison, Wisconsin, USA.
Carmen I CarriónDepartment of Neurology, Yale School of Medicine, New Haven, Connecticut, USA.
Joshua ChodoshDepartment of Geriatrics, New York University Grossman School of Medicine, New York, New York, USA.
Suzanne CraftIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Raina CroffDepartment of Neurology, Oregon Health and Science University School of Medicine, Portland, Oregon, USA.
Anthony FabioDepartment of Epidemiology and Clinical and Translational Sciences, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
Sarah Tomaszewski FariasDepartment of Neurology, University of California Davis, School of Medicine, Davis, California, USA.
Eva L FeldmanDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Felicia GoldsteinDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Stephen A GoutmanDepartment of Neurology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Gina Green-HarrisCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, UW Hospital and Clinics, Madison, Wisconsin, USA.
Victor HendersonDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California, USA.
Thomas K KarikariDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Julia KoflerDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Anna Kucharska-NewtonDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Melissa LamarRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Serggio LanataDepartment of Neurology, University of California San Francisco, San Francisco, California, USA.
Rebecca J LeppingDepartment of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Jennifer LinglerUniveristy of California Davis, School of Nursing, Sacramento, California, USA.
Samuel LockhartDepartments of Neurology and Psychiatry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Jonathan MahnkenDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.
Karyn MarshDepartment of Neurology, New York University Grossman School of Medicine, New York, New York, USA.
Jomol MathewCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, UW Hospital and Clinics, Madison, Wisconsin, USA.
Adam P MeccaDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
Oanh MeyerDepartment of Neurology, University of California Davis, School of Medicine, Davis, California, USA.
Bruce MillerDepartment of Neurology, University of California San Francisco, San Francisco, California, USA.
Jill MorrisDepartment of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Judith NeugroschlDepartment of Internal Medicine, Icahn School of Medicine at Mt. Sinai, New York, New York, USA.
Maureen K O'ConnorDepartment of Neurology, Boston Medical Center, Boston, Massachusetts, USA.
Henry PaulsonDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Richard J PerrinDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Corinne PettigrewDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Aimee PierceDepartment of Neurology, Oregon Health and Science University School of Medicine, Portland, Oregon, USA.
W Ryan PowellCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, UW Hospital and Clinics, Madison, Wisconsin, USA.
Saiju PyarajanCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, UW Hospital and Clinics, Madison, Wisconsin, USA.
Cyrus A RajiDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Eric ReimanDepartment of Psychiatry, Banner Sun Health Research Institute, Sun City, Arizona, USA.
Shannon RisacherIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Robert RissmanDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Patricia Rodriguez EspinosaDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California, USA.
Mary SanoDepartment of Psychiatry, Icahn School of Medicine at Mt. Sinai, New York, New York, USA.
Andrew J SaykinIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Geidy E SerranoDepartment of Pathology, Banner Sun Health Research Institute, Sun City, Arizona, USA.
Vikas SinghCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, UW Hospital and Clinics, Madison, Wisconsin, USA.
Anja SoldanDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
David SultzerSchool of Medicine, University of California, Irvine, Irvine, California, USA.
Christopher H van DyckDepartment of Neurology, Yale School of Medicine, New Haven, Connecticut, USA.
Rachel WhitmerDepartment of Neurology, University of California Davis, School of Medicine, Davis, California, USA.
Thomas WisniewskiDepartment of Neurology, Pathology, and Psychiatry, New York University Grossman School of Medicine, New York, New York, USA.
Randall WoltjerPathology & Laboratory Medicine, Oregon Health and Science University School of Medicine, Portland, Oregon, USA.
Menggang YuBiostastics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Carolyn W ZhuDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mt. Sinai, New York, New York, USA.
Amy J H KindCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, UW Hospital and Clinics, Madison, Wisconsin, USA.
Funding
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8MThe Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)R01AG070883 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2021 to 2026
$42.1MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9MResearch Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BRADFORD C DICKERSON · 2019 to 2026
$36.5MUCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9MWisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5MResearch Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$33.5MResearch Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0MYale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2MResearch Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1MResearch Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI C. Elizabeth Shaaban · 2020 to 2026
$29.4MResearch Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3MNIA/NIH P30 AG079280NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072931NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072973NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072978NIA NIH HHS P30 AG072979NIA NIH HHS P30 AG086401NIA NIH HHS P30 AG086404NIA NIH HHS R01 AG070883NIA NIH HHS R01 AG079280NIA NIH HHS R01 AG083874NIA NIH HHS U24 AG072122NIEHS NIH HHS P30 ES017885
Abstract
introductionThe Neighborhoods Study (TNS) is a novel investigation of adverse social exposome and brain health leveraging 22 Alzheimer's Disease Research Centers (ADRCs). TNS aims to understand if the adverse social exposures increase Alzheimer's disease and related dementias (ADRD) risk.
methodsTNS uses innovative methods to determine lifetime addresses of living (n = ≈ 3116) and brain bank cohorts (n = ≈ 8637). Addresses are linked to time-concordant adverse social exposome using the Area Deprivation Index (ADI) and summarized over time. Brain health measures are provided by the National Alzheimer's Coordinating Center.
resultsWe highlight a general overview and methodology of TNS. Data collection is ongoing; however, preliminary findings indicate that the adverse social exposome is related to ADRD biomarkers, neuropathology, and cognitive function. DISCUSSION: TNS is the largest study of adverse social exposome and ADRD, using the ADRC network to build robust scientific consortia. Its findings will inform ADRD interventions, precision medicine, and policy. HIGHLIGHTS: The Neighborhoods Study (TNS) investigates adverse social exposome and brain health. TNS is a collaboration among 22 Alzheimer's Disease Research Centers. TNS will give insight on environmental and exposomal factors which may be modifiable. Participant lifetime addresses are linked to temporal adverse social exposome metrics. This study's findings will inform precision approaches to mitigate dementia risk.
Indexed as
Alzheimer DiseaseDementiaExposomeNeighborhood CharacteristicsResidence CharacteristicsAgedAged, 80 and overBiomarkersBrainFemaleHumansMaleRisk FactorsBiomarkersadverse social exposomeAlzheimer's disease and related dementiasArea Deprivation Indexbrain healthexposomehealth disparitieslife‐course exposuresneighborhood disadvantageneuropathologysocial determinants of healthThe Neighborhoods Study
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