Evidence map›Paper›PMID 41230777›Full record

ArticleeLife2025

Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases.

Jianing Liu, Anokhi Shah, Xinyu Liu, Joshua L Wort, Yue Ma, Katie Hardman, Niklas G Johansson, Orquidea Ribeiro, Adam Brookfield, Alice Bowen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jianing Liu *Research Program in Molecular and Integrative Biosciences, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0003-0079-4712
Anokhi Shah *BioEmPiRe Centre for Structural Biological EPR Spectroscopy, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Xinyu Liu *BioEmPiRe Centre for Structural Biological EPR Spectroscopy, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.ORCID https://orcid.org/0009-0008-6215-9101
Joshua L Wort *BioEmPiRe Centre for Structural Biological EPR Spectroscopy, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.ORCID https://orcid.org/0009-0001-9162-0429
Yue Ma *BioEmPiRe Centre for Structural Biological EPR Spectroscopy, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Katie HardmanAstbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
Niklas G JohanssonDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-8226-4813
Orquidea RibeiroResearch Program in Molecular and Integrative Biosciences, University of Helsinki, Helsinki, Finland.
Adam BrookfieldThe National Research Facility for Electron Paramagnetic Resonance, The Photon Science Institute and The Department of Chemistry, University of Manchester, Manchester, United Kingdom.
Alice BowenThe National Research Facility for Electron Paramagnetic Resonance, The Photon Science Institute and The Department of Chemistry, University of Manchester, Manchester, United Kingdom.
Jari Yli-KauhaluomaDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0003-0370-7653
Henri XhaardDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Lars J C JeukenLeiden Institute of Chemistry, University Leiden, Leiden, Netherlands.ORCID https://orcid.org/0000-0001-7810-3964
Adrian GoldmanResearch Program in Molecular and Integrative Biosciences, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-8032-9700
Christos PliotasBioEmPiRe Centre for Structural Biological EPR Spectroscopy, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.ORCID https://orcid.org/0000-0002-4309-4858
Keni VidilaserisResearch Program in Molecular and Integrative Biosciences, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-6453-6600

Funding

Biotechnology and Biological Sciences Research Council BB/T006048/1Biotechnology and Biological Sciences Research Council BB/W019795/1Research Council of Finland 1322609Research Council of Finland 13364501Research Council of Finland 1355187Research Council of Finland 308105Research Council of Finland 310297
6 · The paper itself

Abstract

Membrane-bound pyrophosphatases (mPPases) are homodimeric proteins that hydrolyse pyrophosphate and pump H

Indexed as

Bacterial ProteinsEnzyme InhibitorsPyrophosphatasesThermotoga maritimaCatalytic DomainProtein ConformationBacterial ProteinsEnzyme InhibitorsPyrophosphatasesbisphosphonatesDEEREPR spectroscopymembrane-bound pyrophosphatasemolecular biophysicsPELDORS. cerevisiaestructural biologyX-ray crystallography

Identifiers

PMID41230777
PMCPMC12614893

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.