Evidence map›Paper›PMID 41230610›Full record

ReviewDevelopment (Cambridge, England)2025

Searching for physical principles of morphogenesis.

Nikolas Claussen, Fridtjof Brauns, Sebastian J Streichan

Abstract readReview
In one paragraph

Review in Development (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nikolas ClaussenDepartment of Physics, University of California Santa Barbara, Santa Barbara, CA 93106, USA.
Fridtjof BraunsKavli Institute for Theoretical Physics, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Sebastian J StreichanDepartment of Physics, University of California Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0002-6105-9087

Funding

Gordon and Betty Moore Foundation 2919Gordon and Betty Moore Foundation GBMF13800National Science Foundation PHY-2047140National Science Foundation PHY:2210612University of California, Santa Barbara
6 · The paper itself

Abstract

In morphogenesis, biology uses physics to sculpt organs. Understanding this fascinating process requires interdisciplinary collaboration. We highlight recent work in the 'physics of development', with a focus on the interplay between quantitative experiments and mathematical theory. We argue that the role of theory in developmental biology lies in identifying and describing dynamical mechanisms - from the processing of positional information to mechanical pattern formation - independently of their molecular implementation. This level of abstraction provides a structured approach to embrace developmental complexity, but can propose experimental tests to verify its key tenets. We conclude with a sketch of future research perspectives in emerging synthetic morphogenesis systems, which may serve as a platform to distill principles of developmental self-organization.

Indexed as

Developmental BiologyMorphogenesisAnimalsHumansModels, BiologicalDifferentiationMechanicsMorphogenesisPhysicsTheory in development

Identifiers

PMID41230610
PMCPMC12690453

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.