Evidence map›Paper›PMID 41230540›Full record

ArticleProceedings (Baylor University. Medical Center)2025

Hepatitis C virus-related hepatocellular carcinoma mortality: a focus on the US-Mexico border region.

Merry Mathew, Michelle Nguyen, Ketan Jolly, Barath Rangaswamy, Stephanie Stroever

Abstract read
In one paragraph

Article in Proceedings (Baylor University. Medical Center), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Merry MathewSchool of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.ORCID https://orcid.org/0009-0005-7441-3435
Michelle NguyenSchool of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Ketan JollySchool of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Barath RangaswamyDepartment of Internal Medicine, Texas Tech University Health Sciences Center Permian Basin, Odessa, Texas, USA.
Stephanie StroeverDepartment of Medical Education, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In the United States, hepatocellular carcinoma (HCC) mortality is disproportionately high in the US-Mexico border region. This study examined disparities in hepatitis C virus (HCV)-related HCC mortality between border and nonborder regions. Methods: We queried the CDC WONDER Multiple Cause of Death database from 2000 to 2020 for deaths with ICD-10 codes B18.2 (chronic HCV) and C22.0 (HCC). Age-standardized mortality rates (ASMRs) per 100,000 were compared across border and nonborder regions. Significant differences were determined by nonoverlapping 95% confidence intervals. Results: The border region had a 1.6-fold higher overall ASMR (95% CI = 1.5-1.7) than nonborder regions (0.8 vs 0.5 per 100,000). All ethnic groups in the border region had a higher ASMR than their nonborder counterparts, with pronounced risk ratios (RR) in White (RR = 2.0, 95% CI = 1.9-2.1), American Indian (RR = 1.9, 95% CI = 1.2-2.8), and Black/African American (RR = 1.6, 95% CI = 1.3-2.0) people. Within the border region, Black people had the highest risk compared to White people (RR = 2.0, 95% CI = 1.6-2.6), followed by American Indian people (RR = 1.6, 95% CI = 1.1-2.5). Hispanic people also had an increased risk (RR = 1.3, 95% CI = 1.2-1.4) compared to non-Hispanic people. Conclusion: HCV-related HCC mortality is significantly higher in the US-Mexico border region, particularly among Black and American Indian/Alaska Native populations.

Indexed as

Health disparitieshepatitis Chepatocellular carcinomamortality

Identifiers

PMID41230540
PMCPMC12604634

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.