Evidence map›Paper›PMID 41230473›Full record

ArticleAJOG global reports2025

Hypertensive disorders of pregnancy and gestational diabetes mellitus affect fetal growth and perinatal outcomes in women undergoing

Yaxin Su, Yue Niu, Binbin Zhao, Shizhen Su, Cameron Klein, Xiaoyang Hou, Xiao Li, Hong Lv

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJOG global reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yaxin SuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Yue NiuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Binbin ZhaoState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Shizhen SuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Cameron KleinState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Xiaoyang HouDepartment of Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Xiao LiDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Hong LvState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) are common complications that adversely affect pregnancy outcomes. However, data on their independent and combined impacts on fetal growth and perinatal outcomes in Objectives: To investigate risks of abnormal fetal growth and perinatal outcomes following conventional IVF treatment across distinct groups categorized by GDM-affected, HDP-affected, HDP/GDM comorbidity (HDP/GDM), and those unaffected by neither disorder (unaffected). Study design: In this retrospective cohort study, we analyzed data from 20,907 women who achieved singleton deliveries during their first IVF cycles. Multivariate logistic regression analysis was performed to evaluate the effects of HDP and GDM on fetal and perinatal outcomes, adjusting for confounding factors. Results: Compared to unaffected IVF pregnancies, those complicated by HDP alone showed significantly increased risks of small for gestational age (SGA) infants (aOR 5.67, 95% CI 4.56-7.04, Conclusions: IVF pregnancies affected by HDP or GDM exhibit risk profiles for abnormal fetal growth and adverse perinatal outcomes similar to those observed in naturally conceived pregnancies. The combined impact of HDP and GDM significantly exacerbates these risks. Importantly, these adverse outcomes are consistent regardless of whether the embryos transferred were fresh or frozen.

Indexed as

gestational diabetes mellitushypertensive disorders of pregnancyin vitro fertilizationlarge for gestational agepretermsmall for gestational age

Identifiers

PMID41230473
PMCPMC12603730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.