Evidence map›Paper›PMID 41230464›Full record

ArticleFrontiers in veterinary science2025

Isolation and characterization of canine adenovirus type 2 (CAV-HN45) and its selective infection of human cervical cancer cells with preliminary oncolytic potential.

Cong-Rong Wang, Dong-Mei Wang, Guo-You Yin, Yan-Hong Wang, Min Lu, Zhuo-Wei Zhang, Yue Wen, Ding-Zhuo Gao, Jun Hong, Peng-Fei Fu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cong-Rong Wang *College of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan, Henan, China.
Dong-Mei Wang *College of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan, Henan, China.
Guo-You YinCollege of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan, Henan, China.
Yan-Hong WangCollege of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan, Henan, China.
Min LuCollege of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan, Henan, China.
Zhuo-Wei ZhangCollege of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan, Henan, China.
Yue WenCollege of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan, Henan, China.
Ding-Zhuo GaoCollege of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan, Henan, China.
Jun HongCollege of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan, Henan, China.
Peng-Fei FuCollege of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canine adenovirus type 2 (CAdV-2) infects the respiratory tissues of dogs and induces canine infectious laryngotracheitis. CAdV-2 has a high incidence of infection and is easily co-infected with other viruses. Moreover, CAdV-2 is a mammalian adenovirus with characteristics similar to those of Human Adenovirus Type 5 (HAdV-5), making it a promising candidate for recombinant vaccine development and gene therapy applications. In this study, we isolated and identified a CAdV-2 strain (CAV-HN45) and investigated its growth characteristics and viral tropism by evaluating its infection efficiency in various cell lines. Our findings demonstrate that CAV-HN45 can effectively infect cells of swine, canine, and human origin.

Indexed as

canine adenovirus 2characterizationinfection spectrumisolationoncolytic potentialphylogeny

Identifiers

PMID41230464
PMCPMC12604354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.