Evidence map›Paper›PMID 41230456›Full record

ReviewFrontiers in veterinary science2025

The immune microenvironment in tumors: focus on canine and feline spontaneous neoplasms.

Maddalena Rizzi, Giulia D'Annunzio, Chiara Tugnoli, Giuseppe Sarli, Luisa Vera Muscatello

Abstract readReview
In one paragraph

Review in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maddalena RizziDepartment of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Giulia D'AnnunzioExperimental Zooprophylactic Institute of Lombardy and Emilia-Romagna "Bruno Ubertini", Brescia, Italy.
Chiara TugnoliDepartment of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Giuseppe SarliDepartment of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Luisa Vera MuscatelloDepartment of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Companion animals develop spontaneous tumors with biological and immunological features closely resembling human cancers. The tumor microenvironment (TME), particularly its immune infiltrates, plays a pivotal role in tumor progression and immune evasion. This review summarizes current knowledge on the composition and function of immune cells (including T cells, B cells, macrophages, dendritic cells, neutrophils, and mast cells) in the TME of canine and feline tumors. A better understanding of these mechanisms may aid in identifying prognostic biomarkers and novel immunotherapeutic targets in both veterinary and human oncology.

Indexed as

immune checkpointsspontaneous neoplasmsTAMsTILstumor microenvironment

Identifiers

PMID41230456
PMCPMC12604360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.