ArticleFrontiers in neurology2025
Cerebrovascular compromise and cognitive decline driven by chronic heart failure.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study investigated the effects of chronic heart failure with decreased LVEF on small cerebral vascular disease (CSVD) and associated cognitive impairment. Methods: This study encompassed a cohort of 73 patients diagnosed with chronic heart failure (CHF) at the Cardiovascular Department of Suzhou Municipal Hospital, spanning the period from June 2018 to August 2022. Participants were stratified into two groups based on a left ventricular ejection fraction (LVEF) threshold of 50%: 40 patients were categorized into the LVEF≥50% group, representing 54.8% of the cohort, while 33 patients were assigned to the LVEF<50% group, constituting 45.2% of the cohort. Each subject underwent a series of assessments, including brain magnetic resonance imaging (MRI), cardiac ultrasound, and neurocognitive function tests. For the analysis of diffusion tensor imaging (DTI), the tract-based spatial statistics (TBSS) method was employed to evaluate the DTI parameters of the participants' brain white matter. Due to the extended duration of the DTI examination and the stringent requirements for patient compliance, only 37 patients, accounting for 50.7% of the total cohort, completed the DTI scans. This subset included 20 patients from the LVEF≥50% group and 17 patients from the LVEF<50% group. Results: In patients with congestive heart failure (CHF) and a left ventricular ejection fraction (LVEF) of less than 50%, the total Montreal Cognitive Assessment (MoCA) score was significantly lower compared to those with an LVEF of 50% or greater ( Conclusion: Chronic heart failure is significantly associated with the presence of CSVD (especially WMH) and the severity of cognitive impairment, with decreased LVEF correlating with worse outcomes.
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