Biventricular unloading and rhythm control leading to biventricular recovery: a case report.

María de Miguel-Alava, Corry O'Sullivan, Christophe Vandenbriele, Mohamed Osman, Fernando Riesgo-Gil

Abstract readCase Reports

In one paragraph

Article in European heart journal. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

María de Miguel-AlavaDepartment of Cardiology, University Hospital of Valladolid, Ramón y Cajal 3, Valladolid 47003, Spain.ORCID https://orcid.org/0000-0002-4635-9225

Corry O'SullivanDepartment of Heart Failure, Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, Hill End Rd, Harefield, Uxbridge UB9 6JH, London, UK.ORCID https://orcid.org/0000-0002-3396-5226

Christophe VandenbrieleDepartment of Cancer and Surgery, Imperial College, Exhibition Rd, South Kensington, London SW7 2AZ, UK.ORCID https://orcid.org/0000-0001-5151-6400

Mohamed OsmanDepartment of Cardiothoracic and Transplant Surgery, Royal Brompton and Harefield NHS Foundation Trust, Hill End Rd, Harefield, Uxbridge UB9 6JH, London, UK.ORCID https://orcid.org/0000-0003-0439-4951

Fernando Riesgo-GilClinical Lead for Cardiology Transplant Medicine, Department of Heart Failure, Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, Hill End Rd, Harefield, Uxbridge UB9 6JH, London, UK.ORCID https://orcid.org/0000-0002-3094-0867

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Temporary mechanical circulatory support (tMCS) is a life-saving intervention in cardiogenic shock (CS), though not without risks. Increasing attention has been given to ventricular unloading and its role in myocardial recovery, particularly in reversible cardiomyopathies. Case summary: A 35-year-old man presenting with CS was initially treated with veno-arterial extracorporeal membrane oxygenation (V-A ECMO) and Impella (ECPELLA). Due to complications, support was escalated to Levitronix biventricular assist device. After 5 months of support and optimized medical therapy, substantial myocardial recovery enabled weaning from MCS and successful hospital discharge. Discussion: MCS provides critical time to investigate the underlying cause of CS and assess the potential for recovery. This case illustrates how MCS can be both life-saving and a platform for ventricular unloading and neurohormonal optimization. Although full recovery is rare in severe cases, such strategies may improve cardiac function and enable successful weaning from support.

Indexed as

Biventricular unloadingCardiogenic shockCase reportDilated cardiomyopathyHeart failureLeft ventricular reverse remodellingMechanical circulatory support

Identifiers

PMID41230352

DOI10.1093/ehjcr/ytaf536

PMCPMC12604617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.