ArticleFrontiers in dental medicine2025
Sex effects on early life features of the gingival transcriptome.
Article in Frontiers in dental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Background: Epidemiologic assessment of periodontitis prevalence and extent demonstrates age, sex, and race/ethnicity effects. However, the biological sources of these observations regarding sex differences with an elevated incidence in males remain unclear. Methods: This study used a model of experimental ligature-induced periodontitis in young nonhuman primates ( Results: The results demonstrated clear gene expression differences in healthy (baseline) tissues between the sexes, with elevations in females associated with immune responses and elevated gene expression in males related to tissue structural genes. With disease initiation, fewer genes differed between the sexes, although a pattern of a greater number of unique gene expression changes was observed in females at late progression. Overexpressed biological processes showed tissue structural/functional genes at initiation, with host response pathways altered during disease progression. Conclusion: These findings support that this model can be used to explore processes that contribute to sex as a biological variable in periodontitis.
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