Evidence map›Paper›PMID 41230212›Full record

ArticleTurkish journal of chemistry2025

Synthesis, biological evaluation, and theoretical studies of 2-amino-3-cyano-4- (L-phenylalaninyl)quinolines: anticancer potential and EGFR inhibition.

İlbilge Merve Şenol, Begüm Nurpelinx Karaduman Özkan, İlhami Çelik, Ahmet Çağrı Karaburun

Abstract read
In one paragraph

Article in Turkish journal of chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

İlbilge Merve ŞenolDepartment of Chemistry, Faculty of Science, Eskişehir Technical University, Eskişehir, Turkiye.ORCID https://orcid.org/0000-0003-4155-4424
Begüm Nurpelinx Karaduman ÖzkanDepartment of Pharmaceutical Chemistry, Faculty of of Pharmacy, Anadolu University, Eskişehir, Turkiye.ORCID https://orcid.org/0000-0002-0151-6266
İlhami ÇelikDepartment of Chemistry, Faculty of Science, Eskişehir Technical University, Eskişehir, Turkiye.ORCID https://orcid.org/0000-0002-5384-4755
Ahmet Çağrı KaraburunDepartment of Pharmaceutical Chemistry, Faculty of of Pharmacy, Anadolu University, Eskişehir, Turkiye.ORCID https://orcid.org/0000-0002-2503-3824

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quinoline derivatives have garnered significant attention owing to their wide range of biological activities, particularly their anticancer potential. In this study, six novel 4-aminoquinoline derivatives incorporating a phenylalanine methyl ester moiety were synthesized and structurally characterized. The cytotoxic activities of the synthesized compounds were assessed against A549 and MCF-7 cancer cell lines, along with the noncancerous NIH3T3 fibroblast cell line. Compounds 4d and 4e displayed potent anticancer activity with low IC

Indexed as

4-aminoquinolineA549 cytotoxicityDFT analysisEGFR inhibitionMCF-7 cytotoxicity

Identifiers

PMID41230212
PMCPMC12604922

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.